Greetings General! I've been on Rebif for slightly over two years now and have figured out a good routine through much trial and error. I know this is not a popular method, but I find that doing the injections manually is far less painful. You have more control of the speed of the liquid going in than with the Rebiject. If you are able, I would highly recommend it.
Where you inject can also be a factor. I bruise very easily and have a lot of surface veins, especially on my thighs. I have eliminated them from my rotation, as I had too many problems. You also have to watch for capillary beds, which are not always easy to see. I've accidentally hit those before and about landed on the ceiling! It's really helpful to keep a journal on your injection sites and document which areas are good, bad, etc. I also take 400-600 mg of Ibuprofen about 30 minutes before injection and warming the syringe in my hands about for about ten minutes. I occasionally still land a bad spot, but they're fewer and farther between. I hope this helps!