Hi, first posting for me, on Ribif, I went to the 44mg but site reaction too large and painful so went to 22mg. I still have awful site reactions I have been injecting for 3 yrs. I am covered in brown marks from old injections and flaming itchy areas from new ones, I have given myself a weeks holiday from injecting because I am so down in the dumps with the whole thing. The actual injecting side of it is really painful when the needle goes in etc., I have read some older post about other reactions which has started to make me think that could some of my symptoms be the Rebif and not another symptom of MS. Does anybody suffer from spasmotic twitches in random parts of the body, when it happens in my hands v worried about dropping things, the trunk of my body twitch is the worst. Is this just me or what???? Since on Ribif memory worse used to be good with spelling, rubbish now, Speech has become worse. Now is this Ms or rebif, if its Ms then Rebif is doing me no good at all.