I'm new to Rebif as well; I've been taking it for 1 month now. The fever and sore throat are possbile side effects, but I would report them to your doctor. To alleviate your concerns, definitely call the MS Lifelines # and talk to a nurse. Last week I increased from .08 to .22 mcg and felt like I had a hang-over the following morning. The nurse advised me of the importance of drinking lots of water, as the Rebif increases your body temp which can cause dehydration. I really dread taking the .44 mcg and hope I can handle it. As it is, I've been pounding lots of Gatorade and water, but it hasn't alleviated all side effects. I hate having to prepare for my Rebif shot every other day, and then spending the alternate days recovering from the shot. I look forward to when the side effects have decreased!