I 've been diagnosed in February 2001, after a serious attack which, fortunately, left no permanent symptoms, except a tolerant tingling in some of my left hand fingers. I 've been on Rebif since March 2001, and started the 44mcg dose in January 2002. I was doing very well (no attacks, no progression in MRI, no worsening of symptoms) until this summer when started feeling a little worse (both because MS and Rebif) and the side effects got intolerable. I have fever the whole next day, which is enough to make me want to stay in bed.
My neuro said that my body has developed antibodies and reacts strongly against interferon. It seems that Rebif can do nothing for me, anymore.
Anyway, Rebif is good for some people for a couple of years, provided you can tolerate the long-long list of its side effects. I have to admit that the new needles and injector are much better than the old ones, so, for the new user, it will not be such a pain.
Be all well,