I'm another one who does not suffer from the flu-like side effects from Rebif. I have felt them a couple of times in the 4 yrs I've been on it, but in those cases, 2 ibuprofen have provided relief. Like Punchy, the redness at my injection sites takes several weeks to go away so I do an 8 week rotation with 3 weeks on each butt cheek, and 2 weeks on my stomach. I think the shots are painful, and am looking forward to a less painful reformulation (recently reported on this board)being available in the US soon.
Despite the discomfort of injections, I am happy with my choice of Rebif over the other CRABs. What I like most about Rebif (other than the fact that it seems to have stabilized my MS--I am symptom free) is the flexibility of 3 shots per week. Depending on travel and whatever engagements I have, some weeks I do M-W-Sa, other weeks M-Th-Sa, or Su-T-F. I just make sure that I get 3 doses between Sun and Sat, and that there's at least 48 hrs between doses. I chose Rebif over Betaseron and Copaxone largely for this reason...and because it's fewer injections per month. My skin fairly sensitive and it's nice not having to do a shot every day--gives me a chance every so often to forget I have MS.
I do not think I could mentally handle the intramuscular shot of Avonex. And if you believe the data, it appears Rebif is more effective than Avonex anyway.