My lower eyes are puffy (like I haven't slept in a month) and I have an odd color under my eyes. This did start around the time I started rebif. I knew something wasn't right but I can't put my finger on what is wrong. I too discontinued the drug and I still have "puffs".
I am happy you posted this observation, I thought it was only me. I had several sinus problems while on rebif as well. I don't know if this could be related to the nerves beneath the eyes or so on. I have only been off the drug for a few weeks and I'll keep you posted if it "clears up".
One more thing....never refuse to smile because of what your face looks like. Smile because of the way it makes you feel. Laughter is a free drug we don't take advantage of enough!