Is there anything I should be supplimenting the treatment with?
I'm not on Rebif but I have been on Avonex for several years. The two drugs are the same protein just different injection methods and different dosing (subcutaneous injections have about half the absorption efficiency of intramuscular injections so part of the dosage difference is likely to compensate for this fact). Anyways, my first interferon beta injection was pretty intense. I took Tylenol as per the recommendations but it didn't help much. I had one of the worst fevers that I can recall ever having. Essentially, I was down for about 12 hours and didn't get back going at a reasonable speed until 24 hours after my shot. I found that ibuprofen controls the flu type side effects much better than Tylenol. I would recommend taking 400 mg of ibuprofen with your shot and then another dose about 4 hours afterwards. Keep in mind that not all people react the same to interferon beta so the side effects you experience may not be as bad as what other people have been through.
With Rebif, another thing to watch out for are injection site reactions since it's administered via subcutaneous injections. You may get sore spots that stick around for several days or so after your injection. You should rotate your injections sites so that you don't wind up injecting into the same area while you're still having a site reaction. Avonex doesn't have this problem since it's given via an intramuscular injection so it's something I haven't had to deal with personally.
Other things to take? Well, you might want to consider a curcumin supplement which contains the black pepper extract bioperin. Curcumin is an antioxidant found in the spice turmeric which has been found to augment the activity of interferon beta. Check out this research article
I posted a little while back. You want curcumin with the bioperin since it greatly increases the absorption of curcumin.
You might also want to consider taking omega-3 fish oil supplements. I started out taking just a couple of grams of fish oil a day but I'm now taking 6 grams per day. I haven't noticed any effect from the extra oil with regards to my weight. Omega-3 fish oil is anti-inflammatory and it's also good for your brain (refer to the many posts on fish oil in the Natural Approach
forum). I ate very little fish for most of my life, in fact I still don't like it, so I was probably depleted in this essential nutrient.
Let me know if you have any other questions.