I started taking Rebif in June 08.
I decided to stop it at the end of March because I convinced myself it wasn't helping, and I had an increase in depression symptoms with a new onset suicidal ideation.
When I saw my new neuro in April, she insisted I restart the Rebif. I pre-medicated and only injected 1/2 of the syringe, as directed. I woke up in the early morning in rigors, and with a temp of 104F!
I'm back up at 44mcg, and the side effects are mild now. Aleve works a little longer at managing S/E's for me.
On the up-side, I just found out that I only have 2 new lesions since starting Rebif. Most of my symptoms have been from old activity, I guess.
I usually can't inject manually anymore. I use the rebiject most of the time, but I find it's too tough on the stomach and legs. So, when those spots come up in the rotation, I have to ask my DH for help.
Just be careful if you decide to restart Rebif. Demand the titration pack! You don't want to find yourself with severe symptoms when you restart.