Rica, Sarah, Colin Thanks! I appreciate the kind support. It is obvious to anyone reading this post that for me this is not an early intervention, and at this point I feel sufficiently concerned about my other option, aggressive immune suppression to want to do this. Some have PM'd me about doing this concerned that it is not proven. Well, it's not. I'm doing it empirically because in my
situation it is the best option. I am not functioning well at all, short of miraculous new advances I will not make the next treatment option. I have already decided to not use novantrone, though others like it. My family has heart trouble and the cardiotoxic effects concern me.
I have also read the actual citations, not the abstracts, of the work at VU. Anyone interested in trying this ought to do that. There is much more to the theory than is mentioned in these pages or the abstracts. Scientific people would be intrested in details like why the PCR analysis is not reaching the same conclusions in every university (different parts of the DNA being used) and the fact that in mice CPn can cause autoimmunity (mild but present). Read that again. CPn can cause auto immunity, a reaction to self proteins, in mice. Importantly also that EAE when in presence of infxn with CPn is vastly worsened in terms of severity of disease. Another interesting thing, chlamydia trachomatis DOES NOT cause EAE to worsen or colonize the brain. So it's not just any bug, it's CPn. I posted a thread about alzheimers disease having bacteria involed
"bugs in AD even CPn". This points out the affinity of CPn for brain tissue.
About vitamin D. There are two analogs of the D chain that are testable and part of our system. 25 hydroxyvitamin d and 1, 25 dihydroxyvitamin d. The one that is tested and found low in MS is 25-D, though it is a precursor to 1,25-D. My 1,25 was what was tested. (In Marshall Protocol for sarcoidosis the thing is that the 1,25 tends to be high, much higher than the body needs and out of balance. There is some evidence cited by him in his materials that the activated macrophages in the sarcoid lesion make 1,25-D. So therefore, it makes sense in sarcoidosis perhaps to be concerned with high d, though I'm not a sarcoidosis expert of course. Read about it here: http://www.chestjournal.org/cgi/eletters/123/1/18
Also, if you go to pubmed and enter MS and 1,25 dihydroxyvitamin-D you get NO abstracts. None. Since 1,25-D is what Marshall checks, that accounts for the difference. He's looking at something else and it is impacted by other factors.
Now the plot thickens as it so often can in complex metabolic things. If your 25-D is low, you stimilate parathyroid hormone to make more 1,25 so you can continue to function OK because it is necessary to many functions in the body. this stimulation can be so effective you can have a high 1,25 and a low 25-D. I do not know what my 25-D is as it was not tested. I agree that the evidence is compelling that 25-D is low in people with MS and that immune regulation is vitally affected by that. In the abstract Sarah posted above, it mentions a thoery that 1,25 the active analog is the thing that needs to be adequate. As I mentioned mine was high at 52 when 30-40 is good, so I have plenty of 1,25-d. Since I can find no abstracts on 1,25-d in MS (there are a lot of abstracts of 25-d but none on 1,25-d on pubmed. Zero.) we do not know how that tests out for people with MS. SO that is causing the confusion. It's two things.
I will go further after more is known about what my actual level is, but for now, my 1,25 is high enough to let me know it is prudent to wait a bit and see. I do sunbathe and it is summer. I am not worried I'm lacking right now, though whether the high 1,25 is due to PTH stimulation of an otherwise low D status or if it reflects a high overall status is not known in my case currently. In any case D is a fat soluble vitamin and ought to be checked once in a while if you are supplementing. And as I mentioned I sunbathe.
Ok so that's what I know. We will be trying to show the papers I mentioned on the new CPn.org website http://www.CPn Help.org/
though the papers have copyrights that may not allow it. We got them from C. Stratton MD himself and are looking into it. Very cool, huh? Visit the new site and say hello. Jim's been working hard making it nice and it's just getting up now...It's goal is to be a one stop shop for the info related to CPn treatment.