CureOrBust wrote:we are glad to have you here, but I wish none of us had to be here.
Anecdote wrote:Hello Orestes, this is Sarah welcoming you to the site!
mrhodes40 wrote:Welcome Orestes! I agree with Sarah, your Athens is a great person to help you along! I also take LDN. It gives me a great sense of well being compared to before......
Katman wrote:We are all delighted that you found us. .... As I have mentioned before I have an almost uncontrollable (well, uncontrollable) craving for cheese and milk....Rica
Melatonin (MEL), an indole, was originally described as a hormone biosynthesized from L-tryptophan within the pineal gland in the brain; it was found to regulate sleep patterns. Since its discovery, this remarkable molecule has been found have numerous and diverse actions in the cell. MEL is a potent antioxidant, protecting mitochondria from oxidative stress [reviewed by Leon J, Acuna-Castroviejo D, Sainz RM, Mayo JC, Tan DX, Reiter RJ. melatonin and mitochondrial function. Life Sci. 2004 Jul 2;75(7):765-90.] MEL also acts directly on the electron transport chain, increasing ATP synthesis while preventing the oxidative damage associated with such an increase. [Acuna-Castroviejo D, Escames G, Leon J, Carazo A, Khaldy H. Mitochondrial regulation by melatonin and its metabolites. Adv Exp Med Biol. 2003;527:549-57.] These authors also found that MEL restored levels of the important antioxidant glutathione.
MEL is a readily diffusible mobile molecule and is able to pass into any tissue, cell or cell compartment with ease. [reviewed by Hardeland R, Pandi-Perumal SR. melatonin, a potent agent in antioxidative defense: Actions as a natural food constituent, gastrointestinal factor, drug and prodrug. Nutr Metab (Lond). 2005 Sep 10;2(1):22.] These authors observe that, unusually for a hormone, MEL is a normal dietary constituent, and is found in yeasts and plants; walnuts are a particularly rich source. Dietary MEL can markedly influence blood-levels. [Reiter RJ, Manchester LC, Tan DX.Melatonin in walnuts: Influence on levels of melatonin and total antioxidant capacity of blood. Nutrition. 2005; 21(9): 920-4.] The fact that MEL is a normal dietary constituent removes some of the hesitation which one may have in using it for supplementation..............
Thank you for the welcome! It's true-it would have been better not to have to be here, but.....look at it this way (in my case): This MS has been my greatest problem, yet it became the means by which I found that my first love really cares an awful lot about me. Life is strange like this sometimes...the ways it finds to make a point
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