MS Attacks Suppressed By Glucosamine-Like Supplement

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MS Attacks Suppressed By Glucosamine-Like Supplement

Postby HappyPoet » Tue Oct 04, 2011 4:12 pm

For those reading the Daflon supplement threads and for those who don't use the General Forum where this is also posted:

Multiple Sclerosis Attacks Suppressed By Glucosamine-Like Supplement

http://www.medicalnewstoday.com/releases/235342.php

Article Date: 03 Oct 2011 - 1:00 PDT

A glucosamine-like dietary supplement suppresses the damaging autoimmune response seen in multiple sclerosis, according to a UC Irvine study.

UCI's Dr. Michael Demetriou, Ani Grigorian and others found that oral N-acetylglucosamine (GlcNAc), which is similar to but more effective than the widely available glucosamine, inhibited the growth and function of abnormal T-cells that in MS incorrectly direct the immune system to attack and break down central nervous system tissue that insulates nerves.

Study results appear online in The Journal of Biological Chemistry.

Earlier this year, Demetriou and colleagues discovered that environmental and inherited risk factors associated with MS - previously poorly understood and not known to be connected - converge to affect how specific sugars are added to proteins regulating the disease.

"This sugar-based supplement corrects a genetic defect that induces cells to attack the body in MS," said Demetriou, associate professor of neurology and microbiology & molecular genetics, "making metabolic therapy a rational approach that differs significantly from currently available treatments."

Virtually all proteins on the surface of cells, including immune cells such as T-cells, are modified by complex sugar molecules of variable sizes and composition. Recent studies have linked changes in these sugars to T-cell hyperactivity and autoimmune disease.

In mouse models of MS-like autoimmune disease, Demetriou and his team found that GlcNAc given orally to those with leg weakness suppressed T-cell hyperactivity and autoimmune response by increasing sugar modifications to the T-cell proteins, thereby reversing the progression to paralysis.

The study comes on the heels of others showing the potential of GlcNAc in humans. One reported that eight of 12 children with treatment-resistant autoimmune inflammatory bowel disease improved significantly after two years of GlcNAc therapy. No serious adverse side effects were noted.

"Together, these findings identify metabolic therapy using dietary supplements such as GlcNAc as a possible treatment for autoimmune diseases," said Demetriou, associate director of UCI's Multiple Sclerosis Research Center. "Excitement about this strategy stems from the novel mechanism for affecting T-cell function and autoimmunity - the targeting of a molecular defect promoting disease - and its availability and simplicity."

He cautioned that more human studies are required to assess the full potential of the approach. GlcNAc supplements are available over the counter and differ from commercially popular glucosamine. People who purchase GlcNAc should consult with their doctors before use.

Lindsey Araujo and Dylan Place of UCI and Nandita N. Naidu and Biswa Choudhury of UC San Diego also participated in the research, which was funded by the National Institutes of Health and the National Multiple Sclerosis Society.
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Re: MS Attacks Suppressed By Glucosamine-Like Supplement

Postby Bethr » Wed Oct 05, 2011 1:00 pm

Hi HappyPoet, I will be looking into this one and may do a trial with it. i'll post anything interesting that I find. I have had problems with my T-cells behaving badly. Last year I got Pityriasis Lichenoides, where T-Cells erupt through the skin causing blisters. Thankfully it went away fast, but it can be chronic. I have excess T-cells because of a missing spleen since I was 13 yrs old.
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Re: MS Attacks Suppressed By Glucosamine-Like Supplement

Postby 1eye » Wed Oct 05, 2011 2:47 pm

Another EAE mouse cure. All I know about Glucosamine is that my dog's vet said that was why his blood sugar was still out of control, so couldn't have it anymore.
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Re: MS Attacks Suppressed By Glucosamine-Like Supplement

Postby HappyPoet » Wed Oct 05, 2011 3:12 pm

Hi bethr, I really hope this will help you, and I'll send positive thoughts. Very good of you to post about your experience; I look forward to reading how it affects you. I hope to try this if Daflon doesn't help and maybe even if Daflon does help (I linked this thread to the Daflon tracking thread).

Best of luck!
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Re: MS Attacks Suppressed By Glucosamine-Like Supplement

Postby HappyPoet » Wed Oct 05, 2011 4:04 pm

1eye wrote:Another EAE mouse cure. All I know about Glucosamine is that my dog's vet said that was why his blood sugar was still out of control, so couldn't have it anymore.

1eye, read the first paragraph of the article (shown below) again. Isn't this what we've been waiting for from research institutions? And this is a supplement! Not a disgustingly expensive medicine from big pharma. I think this is fantastic!
A glucosamine-like dietary supplement suppresses the damaging autoimmune response seen in multiple sclerosis, according to a UC Irvine study.

Also read this paragraph (shown below) again. Note that humans have been used in other studies *and* "No serious adverse side effects were noted." Did big pharma ever give us anything without horrible side effects?
The study comes on the heels of others showing the potential of GlcNAc in humans. One reported that eight of 12 children with treatment-resistant autoimmune inflammatory bowel disease improved significantly after two years of GlcNAc therapy. No serious adverse side effects were noted.

I'd like to get ahold of the abstract or the full study for this study and for the others mentioned. Help from anyone in finding these HUMAN studies would be much appreciated! Thx :smile:
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Re: MS Attacks Suppressed By Glucosamine-Like Supplement

Postby PointsNorth » Wed Oct 05, 2011 5:21 pm

Hi all,

I just picked up a bottle of NAG (500mg). 60 caps $11.99. I will take 2/day.

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Re: MS Attacks Suppressed By Glucosamine-Like Supplement

Postby Squeakycat » Sun Oct 09, 2011 2:22 pm

Here is a link to the product used in the mouse study.

A human dose IF the relationship were linear would be around 3 grams per day. Mice were getting 1.25mg/25 grams body weight. It is really anyone's guess what the appropriate human dose would be.

The press release on the mouse study says that they are gearing up to do a multi-centered human trial. Maybe the authors would like some preliminary results from informal testing.
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Re: MS Attacks Suppressed By Glucosamine-Like Supplement

Postby PointsNorth » Sun Oct 09, 2011 3:37 pm

Thanks Squeaky,

I've been taking 2500mg/day for the last few days with no noticeable side effects. I will increase to 3000mg for the next week. No changes to report.

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Dosing

Postby Squeakycat » Mon Oct 10, 2011 2:15 am

I looked at a comparable human trial for pediatric IBD which used a total daily dose of 3-6 grams administered three times daily at either 1 gram or 2 grams each time.

Of note was because of hepatic clearance, they had the patients swish the liquid around in their mouth for at least 1 minute before swallowing to get some mucosal absorption.

Only minute amounts are needed to have an effect, but the problem is getting it to where it needs to be given the way it is metabolized.

As far as how quickly an effect was observed in the human, in the pediatric study they comment on this for those who received the GlcNAc rectally, but don't have a similar summary for the speed of the response for those taking it orally.

Of the five responders to GlcNAc monotherapy, one patient had a clinical response within 3 days of starting treatment with complete resolution of bleeding and discharge, two were asymptomatic or with minimal symptoms after 4 weeks and two responded more slowly, with clear improvement noted by 3 months.
Alimentary Pharmacology & Therapeutics
Volume 14, Issue 12, pages 1567–1579, December 2000

A pilot study of N-acetyl glucosamine, a nutritional substrate for glycosaminoglycan synthesis, in paediatric chronic inflammatory bowel disease
S. Salvatore1, R. Heuschkel1, S. Tomlin2, S. E. Davies3, S. Edwards4, J. A. Walker-Smith1, I. French5, S. H. Murch1
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Biopharmaceutic Study Required on GlcNAc

Postby MarkW » Mon Oct 10, 2011 10:35 am

Interesting to hear about the differences in efficacy with different admin routes. Sounds to me like a biopharmaceutics study is needed. Start by obtaining blood levels after IV admin so you get an in vivo half life. Then develop a formulation to get as close as possible, oral one if possible. From the limited info available I would think about a lozenge. Suppositories are only acceptable in France and for small children, it is the best route for many drugs but forget it as a marketing concept.
Micronising the powder may increase adsoption in mouth or gut so needs to be tested. If the research group have a Pharmacy Dept close by they should be able to get the formulation development performed reasonably easily.

If you are trying GlcNAc (PointsNorth and others) then try emptying the capsule into your mouth (via a spoon) and keep it below your tongue for a few minutes before swallowing. I am guessing the GlcNAc tastes OK but do not know.

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Mark Walker - Oxfordshire, England. Registered Pharmacist (UK). 11 years of study around MS.
Mark's CCSVI Report 7-Mar-11:
http://www.telegraph.co.uk/health/8359854/MS-experts-in-Britain-have-to-open-their-minds.html
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Re: MS Attacks Suppressed By Glucosamine-Like Supplement

Postby Squeakycat » Mon Oct 10, 2011 12:15 pm

Mark,

I would think that as popular as glucosamine is, there must be many pharmokinetic studies, though I haven't looked.

The Wellesley Therapeutics Ultimate Glucosamine which was the product used in the study comes as a powder to be mixed in water or other liquid.

Here is a link to the product used in the mouse study.
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Re: MS Attacks Suppressed By Glucosamine-Like Supplement

Postby HappyPoet » Mon Oct 10, 2011 10:09 pm

Squeakycat, thanks so much for finding the pediatric study.

1,000 milligrams = one gram. So, in PointsNorth's case, when she increases to 3,000mg/day, she'll be taking 3 grams/day which is the lower dosage used in the pediatric trial; 6 grams was the higher dosage used.

When I start taking NAG, perhaps in November or December, I'm going to start at 3 grams/day and will increase from there. I bought mine from http://www.Drugstore.com which offers free shipping on orders over $25: Jarrow Formulas N-A-G 750mg which means I'll take two 750mg capsules twice a day to start. Will update.

MarkW wrote:If you are trying GlcNAc (PointsNorth and others) then try emptying the capsule into your mouth (via a spoon) and keep it below your tongue for a few minutes before swallowing. I am guessing the GlcNAc tastes OK but do not know.
Thanks much for this tip.
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Re: MS Attacks Suppressed By Glucosamine-Like Supplement

Postby Squeakycat » Tue Oct 11, 2011 1:56 am

HappyPoet wrote:When I start taking NAG, perhaps in November or December, I'm going to start at 3 grams/day and will increase from there. I bought mine from http://www.Drugstore.com which offers free shipping on orders over $25: Jarrow Formulas N-A-G 750mg which means I'll take two 750mg capsules twice a day to start. Will update.


Just curious, but why try this with a brand other than that used in the original study? Glucosamine products are notorious for not containing what the label says is in the pill. Plus, there may well be some slight difference in the products that matters in terms of bioavailability so that taking something other than what was used in the original study may produce different results.

The Wellesley Therapeutics Ultimate Glucosamine which was the product used in the study comes as a powder to be mixed in water or other liquid.

Here is a link to the product used in the mouse study.
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Re: MS Attacks Suppressed By Glucosamine-Like Supplement

Postby 1eye » Tue Oct 11, 2011 8:40 am

I know glucosamine is not exactly equal to sugar, but it was bad for my diabetic dog's blood sugar. If it were sugar, 3 grams is 30 calories. That is not 30 times the amount of energy required to raise one gram of water one degree C. That is 30,000 times the amount of energy required to raise one gram of water one degree C. Or 30 times the amount of energy required to raise one kilogram of water one degree C. Or 3 times the amount of energy required to raise 1 gram of water 10,000 degrees C.
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Re: MS Attacks Suppressed By Glucosamine-Like Supplement

Postby 1eye » Tue Oct 11, 2011 8:50 am

A teaspoon of sugar is about 4 grams. Doesn't sound like much for 1 day. It was bad for my poodle, but he was small and lethargic.

I think I'll make a T-shirt that says: 2 teaspoons of sugar contains the amount of energy required to raise 1 gram of water 144,032 degrees Fahrenheit.
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