The day before yesterday my neck started tensing up again, so I took .05mg of Clondine and sadly was amazed at how much better it made me feel. Symptoms were slowly creeping back so I didn't notice them.
I was going to try amiloride as it is a milder anti-hypertensive and diuretic but it doesn't really address the cortisol issues much. It's more of a downstream blocker for some of the things aldosterone does. I still might try it some day, but I have a new drug interest for today's visit with my neurologist.
I want to try antalarmin now. It's an anti-anxiety drug that blocks CRH receptors. This would work one step upstream of clonidine and not impact RAAS (ie cause my blood pressure to plummet or shrivel me fingers). I'm thinking CRH might be the bugger that is out of hand with me. Why would my symptoms slowly return with no stress?? Is CRH drunk driving my endocrine system? Anywho, antalarmin should help keep my BBB intact and it has been shown to be protective against development of EAE (which isn't MS but whatever
) Plus, it doesn't impact the parasympathetic system like clonidine does so it should be easier to pinpoint if the cort/aldo cause some of my symptoms. Some related links.
CRH and immune/inflammatory disease http://www.eje-online.org/content/155/s ... 7.full.pdf
CRH and BBB http://jpet.aspetjournals.org/content/3 ... 1.full.pdf
Oral administration of a corticotropin-releasing hormone receptor antagonist significantly attenuates behavioral, neuroendocrine, and autonomic responses to stress in primates http://www.pnas.org/content/97/11/6079.full.pdf
Corticotropin-Releasing Hormone Contributes to the Peripheral Inflammatory Response in Experimental Autoimmune Encephalomyelitis http://www.jimmunol.org/content/174/9/5407.long
I'll be starting a new diary for the antalarmin if my neurologist is willing to prescribe. If it fails, I'll probably be back here at a lower dose or try amiloride. At least they aren't drugs of mass destruction. :shrug:
EDIT: ARRRGGG!!! Antalarmin isn't on the market yet. I guess it'll be amiloride afterall.