This Is MS Multiple Sclerosis Community: Knowledge & Support

Anyone has information on the role of nitric oxide on MS?
I saw several contradictory opinions about it. For erectile dysfunction NO is commonly used. As erectile dysfunction is a common problem with MS patients it would be worth knowing whether it helps or hurts.

Good question. I saw a lot of conflicting info on NO too. I never took time to figure it out though. I think this is might explain why it is bad for pwms.

The Good (in normal people)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1533368/
There's probably a lot more good but I'm too lazy to find it all.

The Bad (in pwms)

http://cdn.intechopen.com/pdfs/34158/In ... e_drug.pdf

http://www.ingentaconnect.com/content/m ... 3/art00015

We have elevated levels of ca2 in MS. If you inhibit ca2 channels, production of superoxide is decreased...which would mean that ca2 is involved in superoxide production and likely causes increased levels of superoxide in pwms. If you add NO, superoxide can react with it creating peroxynitrite, which damages cells and tissues. Pwms have low levels of uric acid which can be attributed to it's "work" in scavenging peroxynitrite. So, I think ultimately, NO is bad for pwms...it helps make more brain eaters.

Hi,

I've been having a good look at this for some time now and I'm not really ready to go into great detail but I can tell you this much; nitric oxide occurs in two ways 1) as constitutive nitric oxide and 2) as inducible nitric oxide. The constitutive forms ( eNOS and nNOS) are fine. The problematic form is iNOS. Inducible nitric oxide occurs when the endothelial layer is damaged. The problem with iNOS is it is much longer lived than the other forms. This elevates the chance that Superoxide will combine with it to create Peroxynitrite. If you have bowel or stomach disorders or gluten intolerances the chances are your endothelial layer is damaged. The way I have dealt with this is to take a teaspoon of the non-essential amino acid L-Arginine as it helps the endothelial layer and promotes eNOS and nNOS rather than iNOS. I haven't taken Avonex for 3 months now to see what happens and I think it has helped.
The peroxynitrite in your system is adversely affecting your ability to make sufficient ATP. I found taken 450mg of Co-enzyme Q10 before bed is the right dose for me. My Superoxide is a result of my EBV infection (that's life). By taking one Valacyclovir tablet per day (I used to need more) I am controlling the production of Superoxide.
Try L-Arginine for the iNoS but you will need to boost ATP and limit Superoxide production as well.

As usual, I remain very well.

Regards

Scott's right---nitric oxide (NO) should remain behind the blood brain barrier. A healthy cerebral endothelium, which is regulated by NO, will protect against iNOS damaging the brain-- a permeable blood brain barrier will not. Think about it like this--iron is an important component of red blood cells, but you do not want iron passing through the blood brain barrier. Iron in plasma is good---iron passing through the BBB, not good. Same with NO.
http://www.direct-ms.org/sites/default/ ... n%2003.pdf

I put together the endothelial health program to help my husband heal his vasculature, and promote a strong blood brain barrier. It involves nutrition, lifestyle, supplements. Here's the research I compiled on NO, the endothelium and MS. Note: you don't take NO as a supplement, you encourage NO production in your body.
http://www.ccsvi.org/index.php/helping- ... ial-health

Glad you're still doing well, Scott! You've really found your path. Jeff remains MS progression free, now six years. Four years since his venoplasty, his gray matter atrophy reversed and his GM now looks normal on MRI.
stay healthy!
cheer

_________________
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
dual stents placed 5/09
CCSVI in MS

Is this an oversimplification? I thought Oxygen travels in the blood through Iron, so having absolutely no iron in the liquid making into the brain, would imply no oxygen making it to the brain. Or is iron suppose to transfer the O2 at the interface (ie the BBB) itself?

yeah...that was a lousy example, Cure. I meant the insoluble iron in heme, but you're right, the brain needs iron, and gets it thru the transferrin receptor of the cerebral endothelium. I shoulda said plasma. Just trying to come up with an example of how something can be good/bad depending on which side of the BBB it resides. Because inhibiting iNOS doesn't help MS, but reducing oxidative stress does. http://www.direct-ms.org/sites/default/ ... d%20MS.pdf
cheer

_________________
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
dual stents placed 5/09
CCSVI in MS

Thanks Scott,
so, L-Arginine is the right stuff. Wouldn't L-Lysine do something similar as Valacyclovir?

Hi Liberation,

Yes, it would but I don't think as potently.

Arginine is a non-essential amino acid that I was very low in when I had my Amino acid studies done so taking L-Arginine just fitted in nicely with thinking about treating the endothelial damage. It may be that taking a butyric acid supplement is even better. I haven't tried that yet as I have not quite finished triple checking that it's the correct thing to do.

The L-Arginine can only help if you don't make enough yourself. The top of the tree in my thinking is to limit superoxide production. We actually need to make some superoxide naturally but we don't want it running rampant and combining with an abundance of iNOS to make peroxynitrite. If we are making to much peroxynitrite with we absolutely be short of ATP and have no energy. By taking a big dose of Q10 I've overcome all energy issues.

Whilst I think interferon is important I'm to see it as an intermediate step and after 15 years of use I may have not the same need for it as in the past. I will go back on it if I think I need it again.

I also try to promote a more alkaline system by taking a teaspoon of bicarbonate of soda each day. I was taking it morning and night but my need has reduced after a year.

The other thing I do daily is drink a large glass of carrot juice. It's the safest way to take in a good dose of Vitamin A. It is hard to get good articles on Vitamin A deficiency but I suspect we were born either to mothers who were low in it or we were born unable to access it appropriately. I don't think we will ever find out the answer to that. The Vitamin A gives you retinoids, particularly all trans retinoic acid and 9-cis retinoic acid. The first is all round good guy and the second activates a receptor called RXR. That receptor is the master switch for the thyroid like receptors which include the option mentioned Vitamin D receptor. I'm afraid I can't see the point in D3 supplements if you don't activate RXR.

Lastly I've added Olive leaf extract to get a good dose of oleuropein. This is the magic element in the so called Mediterranean diet. Oleuropein will activate another receptor called PPAR. If you google it you will see it pretty important.

What I do each day

breakfast
a teaspoon of bicarbonate of soda in a galss of water
greek style (hopefully real) yoghurt
3 boiled eggs
I valacyclovir tablet and a swig of Olive oil extract - you space all this out over the morning. No need to slam it all down
1 large glass of carrot juice

lunch
salad and a lot of something meaty ( i do cheat a lot here)

Dinner
whatever the family eats but I try to avoid gluten

mid evening

a teaspoon of L-Arginine in a glass of water - tastes awful

Before bed

450mg of Q10

That's it

Regards

Thanks Anonymoose. I was just wondering if Viagra and Cialis aren't increasing Nitric Oxide too? Could using them be a problem for MS patients? I would have assumed that excercises increase nitic oxid as well.

Increasing testosterone level and taking Cialis would help solve sexual problems with male MS patients? As far as I know Cialis also increasing the testosterone to estrogen ratio. Is that good for MS?
I assume that the better blood flow resulted in is good.

Hi Again,

Hopefully, this time I won't leave little words out like and make spelling mistakes like the last post I did!

In regard to Anonymoose's post about uric acid scavenging peroxynitrite,I have to say that the low uric acids does not arise because it has been consumed by the scavenging process. It is the low ATP caused by peroxynitrite that results in low uric acid. The uric acid will be insufficient to manage an excess of peroxynitrite and that in itself is a problem. You need to boost ATP production. The Valacyclovir I take is a Purine nucleotide analogue. Purine boosts Uric acid but I have to do something different to boost ATP. That's why I take Q10.

Regards

Liberation,

I don't know much about viagra or cialis except weren't they used to improve blood flow in pwms? I wonder how that turned out. I think I'll leave the nitric oxide to Scott as he's obviously thought and researched more about it than I have.

If you have low testosterone, it could be because your high aldosterone and cortisol production is stealing all the precursors for testosterone. I'm sure it's interference with nutrient absorption doesn't help either.

If you correct those levels using something that inhibits aldo/cortisol production (NOT a blocker), I imagine you will see a cascade of improvements in a lot of your bloodwork levels and in your physical health. I'm hoping to have proof of this in about 5-6 months. I can say in the meantime that I have experienced definite physical improvements and increased libido...the clonidine must be influencing my overall hormone balance (I'm a girl so I don't really know what effect it would have on ED).

Rather than taking a pill for this and a pill for that and worrying about how it will affect the numerous oddities we have with MS, why not just slap a patch on your arm and let everything else even out naturally?

Oh...and about that uric acid...
http://www.ingentaconnect.com/content/m ... 3/art00015
More information about it (and aldosterone's influence on levels) here chronic-cerebrospinal-venous-insufficiency-ccsvi-f40/topic21244-60.html It's near the bottom of the page.

I think maybe Scott and I each have a piece of the uric acid puzzle.

I tried taking an NO supplement which seemed to work for me at first at which point it started to have less desirable affects. I think it was called Qivana or something like that. Scott dissuaded me from using any further.

PN

_________________
Albany 2010. Brooklyn 2011
Hurry up and wait.

Hi PointsNorth,

I didn't know I had that much influence!
I just looked up Qivana, as I don't know it, and it looks like a marketing company. If I don't know what it is I generally don't touch it. That would be the situation in this case.
You could try L-Arginine but like most things it won't do much by itself. If you increase eNOS or nNos you will reduce iNOS and that is the only reason to boost Nitric Oxide that seems to stack up to me. Try to lower superoxide production and boost ATP. What works for me is detailed above. Increased Nitric Oxide is not a magic bullet.

Regards

Just came across a TEDTalk by Richard Weller: "Could the sun be good for your heart?"

http://www.youtube.com/watch?v=Lh9lDWPMWrM

He is claiming it's true people with high levels of vitamin D have less heart disease/cancer, but that people given supplements don't seem to change the risk of heart disease/cancer

"Our bodies get Vitamin D from the sun, but as dermatologist Richard Weller suggests, sunlight may confer another surprising benefit too. New research by his team shows that nitric oxide, a chemical transmitter stored in huge reserves in the skin, can be released by UV light, to great benefit for blood pressure and the cardiovascular system. What does it mean? Well, it might begin to explain why Scots get sick more than Australians ..."

In the talk he says that UVA radiation also causes dilation of blood vessels for up to an hour after exposure on the skin

Edit: found one of his papers:
Journal of Investigative Dermatology (2009) 129, 834–842; doi:10.1038/jid.2008.296; published online 25 September 2008

Enzyme-Independent NO Stores in Human Skin: Quantification and Influence of UV Radiation
http://www.nature.com/jid/journal/v129/ ... 8296a.html

Dr. Richard Weller MD, FRCP (Ed)
email: r.weller@ed.ac.uk
http://www.derm.med.ed.ac.uk/Weller.html
"I have two main research interests. My most longstanding [1-14] area of study has been in the role of Nitric Oxide (NO) in human skin physiology, both in healthy homeostasis and in disease. More recently I have become interested in the role of the skin barrier function deficiencies in the development of atopic disease." -- maybe we could get him interested in CCSVI?