Uric acid is low in MS patients and even lower during relapse. They attribute the low levels to peroxynitrite scavenging. I'm not sure if the levels are even lower in SPMS or PPMS. Here are a few studies I've dug up about it (copied from aldosterone and MS thread). I'm leaving the aldo connection in there because pwms release errant aldosterone constantly. By controlling this release, you might be able to improve uric acid levels. I'm currently inhibiting aldosterone with clonidine and hibiscus tea with very good results. I should have had my uric acid tested before I started but I didn't think of it!
Uric Acid and Aldosterone
Serum uric acid levels in multiple sclerosis patients correlate with activity of disease and blood-brain barrier dysfunction.http://www.ncbi.nlm.nih.gov/pubmed/11985629
Uric acid in multiple sclerosis http://www.ingentaconnect.com/content/m ... 3/art00015
“In animal models, aldosterone infusion causes endothelial dysfunction via the generation of ROS (reactive oxygen species) [22–24]. Aldosterone increases expression of NADPH oxidase subunits p22pbox and gp91phox through an MR-dependent mechanism, whereas aldosterone stimulates expression of p47phox mRNA through both AT1 receptor and MR-dependent mechanisms (Figure 2) [25,26]. The resultant generation of ROS leads to the formation of peroxynitrite”http://submit.clinsci.org/cs/113/0267/cs1130267.htm
Uric Acid: Eplerenone (aldosterone blocker) produced increases in uric
acid to greater than 9 mg/dL in approximately 0.3%http://www.hsc.wvu.edu/Charleston/sop/C ... /jun04.pdf
edited to fix links