on the interconnections between PUFA and zinc status:
In chronic fatigue syndrome, the decreased levels of omega-3 poly-unsaturated fatty acids are related to lowered serum zinc and defects in T cell activation (2005)http://nel.edu/26-2005_6_pdf/NEL260605A22_Maes.pdf
"...lowered serum zinc.. is significantly and positively related to ω3 PUFA levels and the ω3/ω6 ratio . Since zinc is an important cofactor in the synthesis of the long-chain ω3 PUFAs, we have suggested that lowered zinc, which is a marker of inflammation in depression, is one of the causes of lowered EPA and DHA in that illness...
...we found significantly ... lower serum zinc in CFS (mean ± SD=71.7 ± 5.5 µg/dL) than in normal controls (86.0 ± 9.3 µg/dL) [JL: as distinct from 'healthy' or 'optimal' controls which would be more like 120 ug/dL]... we found a significant positive correlation between the ω3/ω6 ratio and serum zinc. These findings are in agreement with those of a previous report showing significant correlations between serum zinc and ω3 PUFAs in major depression ... zinc plays an important role in the desaturase enzymes, which are responsible for the conversion of the essential precursors to the longer chain PUFAs... "
my approach: no meds so far - just nutrient-dense anti-inflammatory whole foods, and supplements where needed
info: www.whfoods.com, www.nutritiondata.com