So what is happening with the magnesium?
Originally, I found the introduction of magnesium lowered my diastolic pressure in particular. This is the measure of how relaxed the heart is between each beat so it can fill with blood. The heart is just a muscle made of the same striated strips of protein as skeletal muscles so the impact should be similar.
Prior to Baclofen, my diastolic was always around 92. After Baclofen it was always around 84. The WHO says normal is below 80. My 17 year superfit son has a diastolic of 54. I am 58 so I’m not chasing him. My superfit 89 year old Uncle also has a diastolic of 54 (Agghhh!!) if he takes his medication. He is an unusual case as he only has half a kidney and is closely monitored.
After I introduced the magnesium the diastolic dropped below 80 (yippee!!) but I struggled to combine it comfortably with Baclofen as described earlier. So what should I look at?
If we revisit my old friend, peroxynitrite, and google that with Magnesium we find these sort of references.http://www.sciencedirect.com/science/ar ... 9302035512http://www.ncbi.nlm.nih.gov/pubmed/12417336
Which introduce a whole new word - sphingomyelinase 1
The important part is the reference that this enzyme is magnesium dependant. There are other sphingomyelinase that are independent of magnesium and other enzymes in the family of sphingomyelinase.
A glance at Wikipedia shows sphingomyelinase and myelin are linked. https://en.wikipedia.org/wiki/Sphingomyelin
“Sphingomyelin is a type of sphingolipid found in animal cell membranes, especially in the membranous myelin sheath that surrounds some nerve cell axons.”
“Sphingomyelins are present in the plasma membranes of animal cells and are especially prominent in myelin, a membranous sheath that surrounds and insulates the axons of some neurons—thus the name “sphingomyelins.”
“Sphingomyelin content in mammals ranges from 2 to 15% in most tissues, with higher concentrations found in nerve tissues, red blood cells, and the ocular lenses. Sphingomyelin has significant structural and functional roles in the cell. It is a plasma membrane component and participates in many signaling pathways. The metabolism of sphingomyelin creates many products that play significant roles in the cell.”
So we are talking about an enzyme that is critical to cell plasma, myelin formation, nerve axons and particularly myelin sheaths.
Peroxynitrite disables Magnesium-dependent sphingomyelinase so it is not available for those critical processes.
As Josephs found –“irreversible inactivation of this enzyme by peroxynitrite generated from SIN1 is likely due to definitive oxidative thiol modification.”
Adding Magnesium makes sense if this is happening.
Just on blood pressure alone, I found this- http://www.ncbi.nlm.nih.gov/pubmed/21818267
It concludes that “Hypertension is associated with marked alterations in vascular sphingolipid biology such as elevated ceramide levels and signaling, that contribute to increased vascular tone.”
In this study on heart disease - http://www.ajcd.us/files/ajcd1211005.pdf
(It won’t let me copy it)
Read page 24 starting at the bottom paragraph. It shows they have demonstrated that Sphigomyelin and calcium bind to each other. This is unhealthy in heart disease but for MS should we look at the enzyme, Magnesium-dependent sphingomyelinase?
Two things stick out to me. If I lack the enzyme because peroxynitrite has disabled it then all my lipids are affected and calcium is released from the cell to bind to the sphingomyelin and secondly that unhelpful release of calcium signals muscles to tighten.
If adding magnesium overcomes this, as it seems to be doing to me then that is a good thing.
Happy to be picked on.