hey there, sublingual methyl b12, D3, calcium and fish oil sound GREAT.
it will probably serve you well to add some magnesium into your regimen. if you can split it up and take 250mg magnesium citrate with your vitamin d3 and calcium, but take another 250mg magnesium citrate at bedtime, you will probably benefit sleepwise and stiffness wise also. the 'best bet diet' supplement recommendations, if i remember right, say 1000mg calcium, 500mg magnesium, and 25-50mg zinc.
consider the antioxidant 'ACES' group - that's vits A, C, E, and selenium. you could either boost food sources, or consider a vit A supplement, some beta carotene, vit C (in addition to fresh fruits and veggies i like to take a couple grams of C powder, in capsules), if you take any vit E make sure
it's natural source E8 complex (or get sunflower seeds/oil in you regularly). selenium requirements can be met with 2 or 3 brazil nuts per day, or you can get 200mcg capsules of powder, which help out too. this is a pretty important blend esp for flu season - selenium (zinc too) are good at helping your body fight off viral and bacterial infections.
does your local MS society chapter have any good naturopath recommendations? i did not find mine through that channel (i called them once and it was so bad, i never called again) - i learned after the fact, that that naturopath was in fact in touch with the local MS society office.
just had a quick look into LDN. it is low dose, so theoretically safer than regular dose naltrexone.. but regular is 10mg and up, while "low" is 1mg to 10mg daily.
usually when i am looking at pharmaceutical products, it's to try to figure out what body system is supposed to be doing that job, and how to support it if possible.
in the case of LDN, i read this basic description:
"LDN exerts its beneficial effects by reducing inflammation and oxidative stress, modulating the immune system, and inhibiting cancer cell proliferation".
just to take a single element from that, we know that the beta-tocopherol in natural vitamin E8 complex inhibits cancer cell growth. it is protective against cancer in different ways than just being an antioxidant like alpha tocopherol (your typical vit E supplement). in fact regular vit E supplements actually drive down beta tocopherol - that's shown in the data from one study... i will have to review my older posts to find that one again...
other than that, i look at how drugs deplete nutrients in the body, and which side effects might be deficiency symptoms, etc. i have a list of nutrients depleted by anti-inflammatory drugs but it's very non-specific so i have no idea if LDN is responsible for any of the following:
Combat Drug-Induced Nutrient Depletion
What Does Your Drug Deplete?
Anti-Inflammatory Drugs (includes Corticosteroids, NSAIDS)...
Calcium, Vitamin D, Potassium, Zinc, Magnesium, Vitamin C,Folic Acid, Vitamin B12, Selenium, Chromium, Vitamin A
anyway hope that helps,