this show always plays during my commute.
CBC - The Current
Listen: http://www.cbc.ca/thecurrent/popupaudio ... 2232476515
Here's the article that caught my ear
"Brain-Wasting: Neurodegenerative Diseases
Today we're talking health and science of a different kind … In a lab in the U.K., researchers believe they've unlocked the mystery around the mechanism that kills neurons in the brain. It is research related to Mad Cow disease or Kreutzfeld Jacob disease but what they're learning could eventually affect how we treat neurodegenerative diseases such as Alzeimer's or Parkinson's."
Related paragraph from UBC's web site
Neil Cashman, professor of neurology at UBC, is in Amsterdam attending the International Prion Conference. He explains the findings of the U.K. study on CBC’s The Current.
“When there is misfolded proteins, when a protein lacks its proper three-dimensional shape, it tends to accumulate and triggers a stress pathway that shuts down the expression of all protein so that the cell can recover from the burden of misfolded protein,” said Cashman. “In neurodegeneration, and especially in the prion diseases, the protein misfolding continues and continues to provide stress.”
of course i was thinking, oh i need to go home and figure out what nutrient supports this protein handling. i hadn't got to it yet, but i was just scouting through the glutathione biosynthetic pathway looking for a zinc-dependent enzyme in the mix, and stumbled on this abstract:
Zinc-dependent protein foldinghttp://www.sciencedirect.com/science/ar ... 3199000708
"Studies of classic zinc-finger peptides over the past 15 years have offered insights into the coupled processes of metal binding and protein folding. Within the past two years, this insight has been used to increase our understanding of the importance of first and second shell contributions (i.e. contributions from direct and indirect metal ligands) to metal binding and protein-folding stability, and led to advances in de novo protein design and protein redesign."
just listening again and they're talking about "endoplasmic reticulum stress"
this looks interesting but not getting any sense this is peer-reviewed: http://www.res-medical.com/endocrine-glands/1787
"Zinc intervention can improve myocardial zinc levels, improve cardiac systolic and diastolic function, and reduce the pathological changes of myocardial tissue, inhibiting the genesis of autophagy and endoplasmic reticulum stress... Zinc intervention can obviously improve renal function and reduce the renal pathological changes, inhibiting the genesis of autophagy and endoplasmic reticulum stress".
anyway. enough of that for the time being.
may 12 update
DIETARY REFERENCE INTAKES FOR Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinchttp://www.nap.edu/openbook.php?record_ ... 6&page=443
"The structural role of zinc involves proteins that form domains capable of zinc coordination, which facilitates protein folding to produce biologically active molecules. The vast majority of such proteins form a “zinc finger-like” structure created by chelation centers, including cysteine and histidine residues (Klug and Schwabe, 1995). "