omg selenium is pretty tough to nail down - look at the variability in these few studies:
this isn't weighted by n for the various studies but all the same:
patient serum averages: 129, 55, 126, 112, 103, 66, 49 (49 is the serum average of patient groups in the last study 53, 55, 46, 41); overall patient average 91
control serum averages: 136, 78, 125, 145, 117, 88, 89; overall control average 111
the only case where selenium is higher in patients is a diabetes study and the numbers are so close that without checking their stats analysis, i don't know how they decided the finding had any significance.
PREDIAGNOSTIC SERUM SELENIUM AND RISK OF CANCERhttp://www.thelancet.com/journals/lance ... 40-6736(83
Selenium levels in serum samples collected in 1973 from 111 subjects in whom cancer developed during the subsequent 5 years were compared with those in serum samples from 210 cancer-free subjects matched for age, race, sex, and smoking history. The mean selenium level of cases (0·129±SEM 0·002 μg/ml) was significantly lower than that of controls (0·136±0·002 μg/ml).
The serum selenium concentration of patients with acute myocardial infarction.http://www.ncbi.nlm.nih.gov/pubmed/3717871
Serum selenium concentration was determined in 49 patients with acute myocardial infarction within 4 hours after the beginning of the symptoms. The mean serum selenium concentration of the patients was significantly lower than that of healthy controls (55 +/- 15 micrograms/l vs. 78 +/- 11 micrograms/l).
Serum Selenium and Diabetes in U.S. Adultshttp://care.diabetesjournals.org/conten ... l.pdf+html
Mean serum selenium levels in participants with and without diabetes were 126.5 and 125.7 ng/ml, respectively.
A STUDY OF SERUM ZINC, SELENIUM AND COPPER LEVELS IN CARCINOMA OF ESOPHAGUS PATIENTShttp://www.canaltlabs.com/pictures/site ... TIENTS.pdf
......................Se (ng/ml)...Cu (ug/dl)...........Zn (ug/dl)
Control Group..145 ± 47.....108.69 ± 16.47.....87.17 ± 6.43
Patient Group..112 ± 32.....142.16 ± 18.72.....75.20 ± 5.57
Serum Selenium Levels in Hemodialysis Patients Are Significantly Lower than Those in Healthy Controlshttp://content.karger.com/ProdukteDB/pr ... /000323538
Multivariate-adjusted means (95% CIs) of serum selenium levels were 103 µg/l (101-105) in hemodialysis patients and 117 µg/l (114-121) in controls.
Study of the correlation of serum selenium level with Behcet’s diseasehttp://onlinelibrary.wiley.com/doi/10.1 ... 016.d04t01
Mean serum selenium levels of patients appeared to be 66.4 ± 15.38 μg/L which was significantly lower than that in the healthy controls (86.87 ± 17.18 μg/L) (P < 0.005).
Decreased serum selenium in alcoholics as related to liver structure and functionhttp://www.ajcn.org/content/42/1/147.abstract
...serum selenium concentration varied from 12 to 88 micrograms/l and was lower (p less than 0.001) in all groups of alcoholics, ie patients with normal liver (53.0 +/- 20.7 micrograms/l, mean +/- SD), fatty liver (55.8 +/- 21.2 micrograms/l), alcoholic hepatitis (46.0 +/- 14.1 micrograms/l), and cirrhosis (41.1 +/- 12.8 micrograms/l), than in 25 healthy controls (88.7 +/- 11.0 micrograms/l).
so what now... i already posted a link to this abstract elsewhere, but a copy belongs here i think
A report of high-dose selenium supplementation: response and toxicitieshttp://www.sciencedirect.com/science/ar ... 2X04000112
"Concerns about the toxicity of selenium has limited the doses used in chemoprevention. Based on previous studies, intakes of 400 μg/day and plasma selenium of 1000 ng/ml (Dietary Reference Intakes, Academy Press, New York, 2000, p. 384) were established as the no observed adverse effect level (NOAEL). This investigation summarizes the plasma response and toxicity reports from 24 men with biopsy-proven prostate cancer who were randomized to either 1600 or 3200 μg/day
of selenized yeast as part of a controlled clinical trial testing selenium as a chemopreventive agent for prostate cancer progression. Subjects were on these doses for averages of almost 12 months. Plasma selenium levels were monitored throughout the course of follow-up. Symptoms of selenium toxicity were assessed by patient interview with specific questions regarding breath, hair and nail changes. Several liver and kidney function tests and hematology were measured at 6-month intervals.
8 subjects were randomized to the 1600 μg/day and 16 to the 3200 μg/day group. The mean plasma selenium levels achieved with supplementation were 492.2 ng/ml (SD=188.3) and 639.7 ng/ml (SD=490.7) for the 1600 and 3200 μg/day doses, respectively
. The 3200 μg/day group reported more selenium-related side effects. Blood chemistry and hematology results were all within normal limits for both treatment groups.
More subjects on 3200 μg/day reported symptoms of selenium toxicity; however, these reports did not correspond to peaks in plasma selenium levels. We observed no obvious selenium-related serious toxicities. As selenium is used in more chemoprevention and therapeutic settings, additional information on selenium species, sequestration of selenium in specific organs, excretion, and toxicities is needed."
also fyi re serum vs plasma se:
Concentration differences between serum and plasma of the elements cobalt, iron, mercury, rubidium, selenium and zinc determined by neutron activation analysishttp://www.ncbi.nlm.nih.gov/pubmed/7233153
"No significant differences in the concentrations of cesium, cobalt, mercury and selenium were observed"
i feel comfortable with dietary se intake plus 200 mcg supplemental daily, but i do know my levels have ended up around 180 from past testing. maybe i'll try selenium every other day for a while and see if anything happens, positive or negative.