Drug-induced Nutrient Depletion http://www.lef.org/magazine/mag2010/aug ... ion_01.htm
"Many drugs are “new-to-nature molecules,” meaning that they are not found in nature, and they never existed in the history of the world until a pharmaceutical company created them. Along with the beneficial effects these medicines provide come side effects, and in some instances, the depletion of nutrients...
...when a woman takes estrogen, it depletes the body of B vitamins, regardless of the form of estrogen (birth control pills, bioidentical hormones that contain estrogen, or synthetic estrogens). A woman taking a birth control pill such as Ortho-Novum® depletes her body of the following nutrients: folic acid, magnesium, tyrosine, vitamin B2, vitamin B3, vitamin B6, vitamin B12, vitamin C, and zinc.1
...Magnesium is a superstar nutrient that plays a role in approximately 300 functions in the body. There are over 100 medicines that cause magnesium depletion such as atenolol, estrogen, and numerous antibiotics such as amikacin, doxycycline, and more.2 Magnesium is a co-factor for adenosine triphosphate (ATP), and is critical in energy production. “Serum magnesium can be normal in the presence of intracellular magnesium depletion, and the occurrence of a low serum level usually indicates significant magnesium deficiency.”3 A red blood cell (RBC) magnesium test would be a better test to determine magnesium deficiency, compared to serum magnesium.
...Steroid drugs such as prednisone4 and triamcinolone5 have been shown to deplete the body of calcium, magnesium, folic acid, potassium, selenium, vitamin C, and vitamin D.
Even the commonest of drugs, e.g., aspirin, depletes folic acid, iron, potassium, sodium, and vitamin C.6 Acetaminophen depletes glutathione.7...
Surprisingly, antibiotics deplete a wide variety of nutrients, and not so surprisingly, they deplete normal gut flora. For example, trimethoprim8 and quinolone antibiotics such as Cipro®9 deplete the body of nearly the same gut flora and the same nutrients: Bifidobacterium bifidum, Lactobacillus acidophilus, biotin, folic acid, inositol, vitamin B1, vitamin B2, vitamin B3, vitamin B6, vitamin B12, and vitamin K."
so, if you're doing drugs AND supplements, testing would be even more important, to determine efficacy of dosing. even though i have published a regimen that works for me, and i make recommendations on doses and timing, i don't really agree with just making blanket intake recommendations for everybody. we're on so many different drugs and so many other things can affect our retention of nutrients, that imo nutritional bloodwork should be the common denominator, regardless of your individual choice of diets, supplements, and/or drugs.
i've known for a long time that oral contraceptives deplete zinc, but it hadn't occurred to me until now (unless i forgot) that it could be part of the picture of women being more likely to get ms compared to men. not to say a female wouldn't get ms if not on the pill, rather in that case the personal zinc depletion part of the overall picture, would not include contraceptive medication.
drug/depletion issues aside, just commenting on the serum/rbc issue: even just using serum magnesium, patients often come back on the low side compared to healthy controls. i think it will be a while before we see good replication of rbc values that will let us zero in on a healthy controls average rbc magnesium.