this is interesting
Erythrocyte zinc content in critically ill patients.http://www.ncbi.nlm.nih.gov/pubmed/16176172
Abnormalities in thyroid hormone metabolism are common in critically ill patients. However, it is not known if these patients are truly hypothyroid at tissue level. Erythrocyte zinc has been shown to be a tissue marker of thyroid hormone status. In this study we have measured the erythrocyte zinc in critically ill patients. In this observational study we measured the zinc content of young erythrocytes in blood samples from 33 healthy subjects, 26 hypothyroid patients, four hyperthyroid patients, and 44 patients in the intensive care unit--22 of these were admitted after a major surgical procedure (surgical group) and the other 22 patients had a variety of conditions (non-surgical group). Erythrocytes were separated according to age by centrifugation. Plasma thyroid hormone concentrations were abnormal in 70% of the critically ill group. Erythrocyte zinc was significantly lower in hyperthyroid patients and higher in hypothyroid patients.
In the non-surgical patients, erythrocyte zinc of young cells (median 256 micromol/L of cells) was significantly higher than (p<0.01) the corresponding cells in the healthy controls (202 micromol/L of cells), whereas in the surgical group it was not different (197 micromol/L of cells). We conclude that in non-surgical critically ill patients, erythrocyte zinc content is higher, suggesting that these patients may be hypothyroid at tissue level.
so i went looking for info on nutritional diffs btw hyper and hypothyroidism. i'm finding that copper zinc imbalance could play in here.
Study of Some Trace Elements in Hyperthyroidism Patientshttp://www.iasj.net/iasj?func=fulltext&aId=31532
"The study showed that serum zinc and selenium level of hyperthyroidism patients were significantly lower (p<0.05) than the level in normal subjects. While a significant increase in serum copper level was demonstrated in patients as compared with that of the normal subjects."
if you check out the full text, table one, you can see that everyone's zinc is low but similar in patients and controls, while copper is much higher in patients vs controls.
hyperthyroid patients had average copper levels in the low 30s umol/L but zinc levels averaging about 8 umol/L.
so if hyperthyroid means low erythrocyte zinc, is copper balance playing into it? i don't know.
now for hypo...
Assessment of Selenium, Copper and Zinc in Hypothyroid caseshttp://www.onlineijra.com/research%20pa ... _cases.pdf
"The range level of Copper and selenium was found to be similar and within normal limits among cases and controls of this region. The level of Zinc was lower in cases as compare to controls"
when you look at table 1, you can see that copper levels are way more consistent between patients and controls than in hyperthyroid cases. zinc is the only thing that is significantly different between cases and controls here.
hypothyroid patients had copper levels around 17 umol/L zinc levels around 15 umol/L after units conversion and, so copper is okay and zinc only needs to come up a little.
in any case, i would suggest that ms patients may be more typically hypothyroid, with the lower serum zinc levels associated with both conditions, and therefore show elevated erythrocyte zinc, possibly associated with copper zinc imbalance characteristic of hypo and not hyperthyroidism.
how's that, clear as mud???!!!