*here i haven't started to measure zinc yet, and i haven't learned about the zinc-uric acid connection, but you see the iron going up and because the uric acid is low, we know the zinc is down too:ok so i did mention the iron problem in a previous post or two, and i have managed to get my hands on some good potent ferrous sulfate in order to address that deficiency. however, i've been getting to feel kind of crappy too.
on another tangent i had been looking at zinc for management of candida albicans, but it turned out to have more links to my overall health than i had anticipated! so in the end i read that high doses of iron can really screw up your zinc. now zinc is a toughie for vegetarians, and when you add in that high dose of iron then you're really in for some fun. the jimmylegs made an emphatic reappearance over the last few days. but now am taking some big zinc doses along with the iron, and will keep u all posted on the outcome. legs seem fine now after only two doses of zinc, and i have noticed instant outcomes from supplements in the past, but i want to see if the legs are jumping this eve before i have any confidence that the situation has been put onto the right path again. freaking nutrition. lol!
*i'm still not measuring zinc. i'm working to keep my ferritin status in line, and the pesky low uric acid numbers provide the clues to persistent low zinc levels.i have been working on a number of nutrients but the last set of tests were for vitamin B12, 25(OH)D3, and Iron. ...
the iron has gone from deficient (under 20 i believe) to 78. normal range 20-180. so, feeling good about that.
now, on to uric acid. at the last test i was 194 µmol/L (3.26 mg/dL). normal is 140-340 µmol/L (3.0 - 7.2 mg/dL). however, the study below places my nice little uric acid value right in the ms camp. so my next task is to get the danged UA up into the "control group" range. garçon! some liverwurst, s'ilvousplaít!
*i go back over things, reconnect zinc iron interactions, and here we go with another round of balancing.serum ferritin is now 64, it was 36 a year and a bit ago. this probably reflects a few rounds of supplementation and the switch to eating animal products. so that's all good. ... uric acid is a shocking 185. this is bad news as i was at 194 early in 2006 when all the $h!t hit the fan, and i was trying through eating meat to get up to the optimal 290 level. i will have to get on the inosine bandwagon, but in the meantime will eat steak and kidney pie every day for a week and see how that pans out hehehe! [2012 comment: WRONG WRONG WRONG. do not throw high purine foods into a zinc deficient body that can't effectively make the conversion from ammonia to urea to uric acid. you'll just drive up your ammonia levels....
*ooh look at me, maybe things are starting to stick (can you say cognitive issues...)... i remembered that my second bout with the jimmylegs problem ... was partly iron, but rereading this forum, i realize it must have been zinc working with iron so have added zinc back into the daily mix for a while, will keep yas posted. only started taking the zinc last night and there hasn't been a jimmyleg incident yet today but we shall see!
*and here i FINALLY start measuring ferritin, zinc AND uric acid at the same time (BUT have totally gapped on the iron zinc balance. re-read early notes AGAIN.. discover the connection AGAIN..):new stuff:
-finally started back in with the iron liquid about three days ago, so added 50mg zinc per day to go with it..
*now, i am pretty solid on the zinc-jimmylegs connectionokay, so since my last post i have been really slacking on the supplements, ... it's about time to get back on the supplement regimen again, as the legs have started to go jimmy again and everything.
serum ferritin;................82; (51 - 140); "probably not iron deficient"
Uric Acid;....................194; (150 - 350)
zinc;.........................8.6; (11.5 - 18.5)
... so for ferritin: gotta get it out of that "probably not" range into the "definitely not" range. because of that thing where iron assays over-represent your levels if you have an "autoimmune" condition.
... uric acid: BOO! stupid ms average, on the dot, AGAIN. food is not doing the trick, apparently.
... zinc: interesting. i had not looked carefully through my posts once my legs went squirrelly during this last long layoff from the supplements. i kept having good intentions and then slacking. the legs started to jimmy out on me again. i remembered an iron connection. i have purchased some within the last week and it worked somewhat. now my bloodwork shows low zinc. i just re-read my posts more thoroughly to note how while in australia i had connected the remaining jimmylegs issues to zinc, to resolve it the rest of the way.
so, i'll take zinc with meals, iron in between, and let you know if the jimmy thing backs off again..
*definitely on top of it here...little zinc update. i took 2x 15mg pills a few times, but the legs were still kind of jumpy. last night and through today, i have taken 2x 50mg zinc pills, at three separate times.
it came to me that if my zinc was deficient in november, and i hadn't taken any since then, that the situation probably was more dire than the 8.6 so i'm hitting it harder than i usually would. i think it is starting to work but will keep an eye on it and post tomorrow's jimmyleg status after some more 100mg zinc doses. or maybe i'll drop back to 50 at a time. depends how the legs are doing!
*and... zinc goes high for the first time!!! strong suspicions that I mentioned iron specifically as a strategy for managing this 'high' zinc level.i was lying in bed this morning, and felt a sudden spiky itch, like a pinprick, in my right foot. a couple of days ago my leg would have shot up in the air in response, but today i just felt a very slight suggestion of tension. mind you i felt sick to my stomach after my bedtime 100mg dose of zinc last night, so i'll probably back it off to 50mg per meal for today, and report back on the jimmylegs later. i'll set up an appointment for my D3 megadose prescription, and a zinc test requisition too, so that we can see if my zinc level is attaining normal range as the legs settle back down.
*a second set of tests looking at Fe Zn and UA all at onceokay drum roll please...
zinc normal range: 11.5-18.5
nov 30 zinc test: 8.6
jun 9 zinc test: 20.6
(june 9 test was after a 1 week washout with no zinc supplementation but i forgot and did have food that day prior to the test)
moral of the story: prioritize the follow up test. i shouldn't have let it go that long.
next step: check on my uric acid. and take iron for a couple weeks.
*next, zinc goes quite a ways down.. and look at that, up popped ferritin. no coincidence there... ASIDE: look at that zinc copper ratio ABSOLUTE GARBAGE! dangerousso, went for my bloodwork this morning - b12, d3, ferritin, RBC folate, uric acid, copper, zinc and magnesium. big pile o phials.
may 5 2009all right, some preliminary numbers are in from the lab..
11/30/07 4/17/09 range target
zinc 8.60 11.60 11.5- 18.5 ~18.2umol/L
UA 194.00 255.00 140.0-360.0 ~300nmol/L
fe 82.00 91.00 10.0-291.0 TBD ug/L
mg .88 .94 .7- 1.0* >0.9mmol/L
cu N/A 18.20 11.0- 30.0 TBD umol/L
ZINC ...only 11.6. have had another test since then, read on...
URIC ACID is AWESOME. i read some studies that had me thinking the UA status would improve once i dealt with that zinc deficiency. TRUE! still have a ways to go, though.
IRON ferritin 82 ug/L was "probably not iron deficient" and so is 91. you have to get up to 140 to be "not iron deficient" and over 400 is "possible iron overload". i'm happy with it being a little better. .
jul 7 2009got some more info from the lab today, and updated the table accordingly, above (prev page, that is).
zinc came in still quite low at 11.6. i'm surprised the uric acid increased so much when i only got the zinc raised from 8.6 in nov '07 to 11.6 now (not counting that high blip in early '08!)
once i get the mix right and can keep the zinc closer to 18, i am hoping my uric acid levels will be right up near 300..
*more toying with the balance. i was way more interested in the zinc UA correlations but the ferritin number is interesting. yes when zinc intake drops you'd expect UA to drop too, but it's interesting and consistent that the ferritin has jumped as well. for whatever idiotic reason it actually looks like I simultaneously increased supplemental iron and decreased supplemental zinc. way to go, genius:jun 19 labwork is starting to come in.
i actually overdid it with the D3!?!
instead of getting it up to 150 like the first time, this time around it went from 103 to 271 nmol/L!!!
i think this might be because of fixing the zinc deficiency, but i'm not clear on exactly how yet.
more good news re: zinc and uric acid. i'm up to 16.1 with the zinc, and the uric acid has jumped again, right in synch - it's at 278 now!!! only 12 more to go..
feb 9 2012preliminary bloods are in already. that was fast. ...
urate (uric acid) 230 umol/L
balls. that is an 'ms patient in remission' average, according to research, not a healthy control number at all. will need to get this up to 290-300 umol/L. this bad result probably means my zinc levels are crap too, we'll see. i had been cutting back on zinc supplements over the last while, ie 50mg every other day rather than every day, to test if i would still be okay. guess not :S might be an issue with % absorption per pill - i probably don't actually absorb the full amounts stated on my multi and separate 50mg zinc/2mg copper pill.
ferritin 153 ug/L
fine and dandy. i like to be at least 100. my lab's ranges seem to have changed and show normal as 80 to 300 now, rather than 100 to 300. don't know why. i wouldn't want to go over 200 necessarily, but you know how i feel about ranges in general practice...
anyway based on this result (high-ish for me) i think i may be able to quit supplementing extra iron around 'that time of month'. looks like my red meat intake (1-2 servings every 6 days) plus the multi may be sufficient..
zinc = 14.6 umol/L better than expected but still not good enough. definitely in the 'ms' sector of the 'normal' range.
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