If you have JCV then Tecfidira would not be suitable ( http://www.medscape.com/viewarticle/856148
It's not clear what your other issues are or why IVIG was needed for such a long time. That sort of treatment is trying to reset your immune system.
All my real world experience is here - regimens-f22/topic24019.html
but it's long and messy and complicated.
In simple terms I aim to a) identify any infections and clear them out particularly the less obvious ones like chlamydias, mycoplasmas or any gram positive bacterial infections etc b) use valacyclovir as I have an EBV history c) take CoQ10, aceytl-l-carnitine to help me make energy d) take Curcumin because it shifts the immune response from Th1 to Th2 (like half the drugs) and e) take N-aceytl-cysteine as it counterbalances homocysteine (an inflammatory marker). Additionally, I take a very low dose of 5mg Baclofen before bed because that is as much as I can handle and 25mg twice daily of Dantrium. Those last two are on prescription for spasticity (I was very tight) and the Dantrium really works. The only issue is it makes you feel weak for a week or so when the tightness is released and your weakness is exposed. The only answer to that is exercise like pilates to cover all the muscle groups at least three times a week.
I did take Avonex for 10 years and haven't for the last decade. Hated it and don't miss it at all. I don't obsess about diet but I avoid processed or added sugar and stay away from gluten. Breakfast is the key meal of the day (apple juice, banana, 2 eggs, and a whole avocado) and each day starts with a good quality probiotic.
That's about as real world as I can be.