I am so sorry I didn't see your questions until now.
My questions are: with the FDA position on bio identical hormones, is it still possible to get Estriol from a compounding pharmacy. And for those of you who do take it, how long before/if you notice any improvements?
Yes, it's possible to obtain estriol. Here's the FDA link on the topic: Obtaining an IND for Estriol
I'd say it was about 3 months before I noticed an improvement in symptoms.
I live in a small community, how do you find someone to prescribe Estriol? Also, her question was how much progesterone should go with it? Is it possible to contact Dr. Voskuhl or some other person leading in the research to get more information to my Doctor?
If there's a compounding pharmacy or naturopath in your community I'd contact them and ask if they know physicians who might prescribe. I'll also pm you with some info.
Personally I think the progesterone dose should be based on the results of your hormone testing (which I highly recommend). Turns out I had zip and ultimately ended up on 500 mg.
I haven't been in contact with Dr. Voskuhl. But, here's some info that hasn't been posted in this thread (not specific to estriol though):ACTRIMS 2007 Program
P20 (on page 47 of the program) HRT Contributes to Neuronal Health in Postmenopausal Women With MS
Kathleen Fuchs, PhD
University of Virginia, Charlottesville, Virginia, USA
Oral estriol treatment is associated with a decrease in number and volume of gadolinium enhancing lesions on MRI. This suggests that estrogen products offer some degree of neuroprotection. To date, it has not been demonstrated if postmenopausal women with MS derive disease-modifying benefit of hormone replacement therapy (HRT).
Objectives: In a pilot study of postmenopausal women with MS, 1H MR Spectroscopy (MRS) was used to compare the level of N-acetylaspartate (NAA)—a putative marker of neuronal integrity—in women with and without HRT.
Methods: We evaluated 16 women with clinically stable MS—8 on HRT, 8 not on HRT.
Results: The groups were comparable in age (mean50.5 years, p0.07) and disability level as assessed by the MS Functional Composite (mean z0.08, p0.72).....
There was a significant difference (p0.015) in the NAA/Cr ratio between the women on HRT (1.910.39)and the women not on HRT (1.410.32).
When age, level of disability, and use of immunomodulatory therapy were used as covariates in the statistical analysis, the significant difference between the groups remained.
Conclusions: In this small sample, we demonstrated that use of exogenous estrogen may contribute to neuronal health as measured by MRS. These findings will need to be replicated in a larger sample to determine if the benefits of HRT outweigh the risks in this population.
Now, I wanted to let everyone know that they're still recruiting for the estriol trial. MS Trial Alert: Clinical Trial of Sex Hormone Estriol Recruiting Women with MS to Participate - Updated
"Estriol treatment also has the potential to be more potent in halting disability in MS, since estrogens have been shown in animal models to be not only anti-inflammatory, but also to directly reduce brain injury."
Again, so sorry Peggy for the "slow" response.