http://www.ncbi.nlm.nih.gov/pubmed/20170394The underestimated problem of using serum magnesium measurements to exclude magnesium deficiency in adults; a health warning is needed for "normal" results.
Here is a recent paper from BNAC which looked at sunlight exposure and brain volume on MRI in people with MS. They did not look at NO--but Dr. Weller is proposing a new study to do just that. This is all new research....
Increased summer sun exposure was associated with increased grey matter volume (GMV, r(p)=0.16, p=0.019) and whole brain volume (WBV, r(p)=0.20, p=0.004) after correcting for Extended Disability Status Scale in the MS group. Inclusion of 25-hydroxy vitamin D3 levels did not substantially affect the positive associations of sun exposure with WBV (r(p)=0.18, p=0.003) and GMV (r(p)=0.14, p=0.026) in the MS group.
Sun exposure may have direct effects on MRI measures of neurodegeneration in MS, independently of vitamin D.
eNOS is activated by physiological and metabolic stimuli, shear stress, and receptor-dependent agonists to functionally inhibit platelet aggregation, leukocyte adhesion, and smooth muscle cell proliferation, as well as to maintain vascular tone. Oxidative stress uncouples eNOS-derived NO, increasing ONOO- production, which leads to endothelial dysfunction.
We have a brand new peer-reviewed paper from the researchers of the ISNVD which is considering the vascular connection to MS. It is called:
"Blood circulating microparticle species in relapsing–remitting and secondary progressive multiple sclerosis. A case–control, cross sectional study with conventional MRI and advanced iron content imaging outcomes" This paper is published in the Journal of Neurological Sciences.
http://www.jns-journal.com/article/S002 ... 3/abstract
Endothelial function: Folic acid has been shown to prevent postprandial endothelial dysfunction in normohomocysteinaemic subjects, and to improve endothelial function in patients with hyperhomocysteinaemia, hypercholesterolaemia, diabetes and coronary artery disease.3 The exact mechanisms underlying the ameliorative effects of folate on the endothelium are uncertain, but may include homocysteine-lowering, antioxidant actions, effects on cofactor availability, or direct interactions with the enzyme endothelial nitric oxide synthase.11-13
Users browsing this forum: No registered users