Reversing Endothelial Dysfunction

Tell us what you are using to treat your MS-- and how you are doing.

Re: Reversing Endothelial Dysfunction

Postby Scott1 » Fri Jul 18, 2014 5:09 am

Hi Cheer,

I have no doubt UV is important. It's just in Australia we have an abundance of it yet the issues we are dealing with still persist. There has to be more to it so the issue you are dealing with will be about how UV can disrupt the cause of veinous narrowing rather than lack of UV being the cause. Why there is problem with Nitric oxide dilating blood vessels would be the question for me.
The Swedish study describes an almost impossible scenario in Australia yet we have plenty of examples of MS.

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Re: Reversing Endothelial Dysfunction

Postby THX1138 » Fri Jul 18, 2014 9:06 am

When it comes to Reversing Endothelial Dysfunction, I believe that Magnesium plays a larger role than people are led to believe by lab tests. Magnesium is difficult to measure properly and the most common test will usually mislead both doctors and patients:
The underestimated problem of using serum magnesium measurements to exclude magnesium deficiency in adults; a health warning is needed for "normal" results.
http://www.ncbi.nlm.nih.gov/pubmed/20170394

Magnesium is a vasorelaxant.

Just the other day I had a revealing experience with Mg: http://www.thisisms.com/forum/post227167.html#p227167
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Re: Reversing Endothelial Dysfunction

Postby cheerleader » Sat Jul 19, 2014 11:43 am

Scott--Please watch Dr. Weller's video---he explains UV rays and how they release NO from dermal storage better than I ever could. His studies were done on humans, and he has vitally important information. I never said it's a cause...I said it is one important component. He discusses Australia, as well. You can have great sun and UV, but spend all day indoors and never get UV, and that's a problem. Honest, it's worth 10 minutes.
https://www.ted.com/talks/richard_welle ... your_heart

But reversing endothelial dysfunction is multi model. It involves nutrition, exercise and lifestyle. What we eat, breath, and how we live.

Yes, Mg is incredibly important, yes, UV is important, too. But so is moving every day (to create vascular shear stress), reducing stress (to reduce cortisol), not smoking (a known vasoconstrictor), not eating transfats (damaging to endothelial cells), not eating processed foods or too much sugar. Sleep is essential, laughter helps. Vitamin D and B12 are necessary. We are complex organisms. Never going to be about one pill, one supplement, one adjustment or one size fits all. It is about a complete, individualized lifestyle. Every day.

Here's the whole program. It works. But it takes work.
http://ccsvi.org/index.php/helping-myse ... ial-health

cheer
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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Re: Reversing Endothelial Dysfunction

Postby Scott1 » Sun Jul 20, 2014 1:57 am

Hi Cheer,

I have no argument with anything you have said except I would start earlier in the process. The post I put up a couple below this one also highlights the role of megalin in Vitamin D transport, the role of the retinoid X receptor, how ADMA influences nitric oxide synthase and how superoxide combines with nitric oxide to make peroxynitrite.
It's fascinating how UV helps vasodilation. It also works against hydrogen peroxide and peroxynitrite. I agree it's a multifaceted thing.
My only issue is the question of Vitamin D itself. Undoubtedly it's important but I'm a bit concerned it gets an elevated status it might not deserve. It feels to me that when serum Vitamin D is elevated the outcomes are not consistent and in a large part of the healthy population the level cycles with sunlight but no adverse affect generally arises as the level falls. I'm sure the UV helps and I agree vasodilation helps, I'm just not so sure about Vitamin D. It might be the politician in the office rather than the genuine worker. I never worry about Vitamin D but I obsess about vasodilation, mitochondrial respiration and activating RXR and I'm very well. I did work very hard on EBV because it caused the expansion of superoxide but I think I won that war after a decade.
Happy to be proven wrong as I still think it's the sum of things that matters.

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Re: Reversing Endothelial Dysfunction

Postby cheerleader » Sun Jul 20, 2014 9:48 am

Did you watch the video, Scott?
https://www.ted.com/talks/richard_welle ... your_heart

Dr. Weller explains that vitamin D levels may purely be a biomarker of UV exposure.
Many benefits of sunshine are outside of Vit. D creation. Which is why supplementing vitamin D isn't enough.
Watch the video, Scott...we're saying the same thing :) Honestly.

Nitric oxide (NO) does more than dilate vessels---it also protects organs, stimulates the brain, kills bacteria and viruses http://www.nobelprize.org/nobel_prizes/ ... press.html
I'm not here to "prove" anyone wrong...just trying to bring to light some fascinating research on how UV affects the human body, outside of vitamin D, by releasing NO stores from the skin. And maybe encourage people to go outside and get some sun. We do that everyday in southern Cal.

Here is a recent paper from BNAC which looked at sunlight exposure and brain volume on MRI in people with MS. They did not look at NO--but Dr. Weller is proposing a new study to do just that. This is all new research....

Increased summer sun exposure was associated with increased grey matter volume
(GMV, r(p)=0.16, p=0.019) and whole brain volume (WBV, r(p)=0.20, p=0.004) after correcting for Extended Disability Status Scale in the MS group. Inclusion of 25-hydroxy vitamin D3 levels did not substantially affect the positive associations of sun exposure with WBV (r(p)=0.18, p=0.003) and GMV (r(p)=0.14, p=0.026) in the MS group.
CONCLUSIONS:
Sun exposure may have direct effects on MRI measures of neurodegeneration in MS, independently of vitamin D.

from my blog on Vitamin D status and 5 Year MS Study
http://ccsviinms.blogspot.com/2014/01/v ... study.html
cheer
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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Re: Reversing Endothelial Dysfunction

Postby Scott1 » Mon Jul 21, 2014 1:42 am

Hi Cheer,

I agree. We are in enthusiastic agreement.

I did have a problem watching the video thanks to a faulty windows 8.1. All fixed now.

The vitamin D is processed in the renal proximal tube and that is a long way from direct sunlight. There is clearly a chemical process in the skin activated by sunlight which is quite fascinating. Also,don't forget you need nitric oxide to make peroxynitrite. That's the bad guy in my view and it needs an abundant supply of superoxide to combine with nitric oxide. Nitric oxide is a good guy but it needs eNOS and nNos working not iNOS.

For a example of how using UV can break down the influence of radicals in the skin have a look at this - http://www.fasebj.org/content/early/201 ... 9.full.pdf

The pictures are striking.

For an example of the damage peroxynitrite can do read this - http://inotekcorp.com/publications/pdf/ipcpub291.pdf

UV has a real role to play.

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