jimmylegs wrote:probably the same deal for statins and niacin, whaddaya reckon
jimmylegs wrote:probably the same deal for statins and niacin, whaddaya reckon
cheerleader wrote:64 million dollar question (thanks, Marie):
Why do steroids and chemo work on alleviating MS
NHE wrote:cheerleader wrote:64 million dollar question (thanks, Marie):
Why do steroids and chemo work on alleviating MS
I don't mean to start an "autoimmune vs. not autoimmune" argument. However, corticosteroids, such as prednisone, induce white blood cells to enter into apoptosis which is programmed cell death. By lowering the total number of white blood cells, the corticosteroids are also lowering the number of cells targetting myelin related antigens (e.g., the MRTCs which were the focus of the Tovaxin study).
NHE
My opinion, no matter what the actual cause of something, if a drug attacks it from a different angle, it can appear to be "effective".cheerleader wrote:My question was proposed hypothetically....what if MS is vascular? Why would steroids/chemo help? No one is debating their effect on the immune system. I was merely commenting that they also affect the vasculature and create vasodilation, and are used by haematoloists to relieve clotting disorders. This might be another reason why they help during MS exacerbations. Only my opinion...
CureOrBust wrote:No one has shown that the vasodilation or blood thinning tablets have helped MS, yet many immune modulators HAVE been proven to help MS.
Do you have a date yet?gibbledygook wrote:I'm being referred to a doctor for Doppler imaging of the venous blockages! V excited.
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