This from what I understand is what causes most of my spasticity, clonus, hesitancy, and foot drop. I do have fatigue, and this effects my ability to keep a conversation at the end of a day, and I do need a nap every now and again depending on what I'm doing. I take Amantidine for it and it helps mildly.
You hit on a subject which I think is going to be especially interesting to see the data coming from HDC studies, and that is, what exact symptoms are caused by MS specifically and which symptoms "come with the package" as part of the spectrum
An almost obvious assumption would be that fatigue originates in the brain and therefore would be specific to MS. Although fatigue might in fact originate in the brain, fatigue isn't unique to MS and is a common factor in most autoimmune diseases and therein lies, what I consider, Tovaxin's biggest shortcoming.
Tovaxin ONLY removes the self reactive cells specific to MS. When Opexa makes a similar treatment for T1 diabetes, it's ONLY going to remove the self reactive cells for diabetes. The problem is that a lot of people have more than one autoimmune disease and a way higher number of people diagnosed with MS have symptoms of other autoimmune diseases which haven't been diagnosed. Being treated with HDC will, or at least should, leave recipient free of all autoimmune diseases. Despite being driven by different Th responses, I'll also be interested to find if people treated with HDC find that allergies and asthma disappear.
I guess that's just one of many reasons it will be interesting to follow Brett's progress through this!