Helen Blau, Ph.D., and colleagues from Stanford University injected bone marrow from adult mice that express a marker called green fluorescent protein (GFP) into adult mice that had been irradiated to eliminate their bone marrow. They found that bone marrow-derived cells migrated into several regions of the brain, including the olfactory bulb, the cortex, the hippocampus, and the cerebellum. Some of the marrow-derived neuronal cells also grew long fibers and produced a protein that indicates cell activity. These results suggest that the marrow-derived neurons not only entered the brain but also responded to their environment and began to function like the native ones.
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