MBP8298 vs Copaxone

A board to discuss Revimmune as a potential therapy for multiple sclerosis

MBP8298 vs Copaxone

Postby Cyclops » Mon Jul 21, 2008 1:02 pm

I was just reading about MBP8298. It is intended to teach the immune system to tolerate myelin rather than attack it. As I understand it, this is the intention behind giving Copaxone after Revimmune. Maybe MBP8298 could be even better?

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Postby Loobie » Mon Jul 21, 2008 3:20 pm

The thing I like about MBP's approach is that it's aimed at secondary progressive. That's huge to a lot of MS'ers. Not sure about the Copaxone thing after Revimmune, but I know if you emailed Chris at Chrishasms.com he could fill you in. He has a pretty tight understanding of the entire process, as I suppose all the HiCy'ers do!
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Postby Jamie » Mon Jul 21, 2008 6:54 pm

agreed, in fact i pm'd bob this very same thought
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Postby RedPenguins » Mon Jul 21, 2008 7:35 pm

Good question re: copax vs. MBP... I imagine the reasoning is in line with what Loobie said. I think copax was more specific in that after pre-treating mice with it, they found the mice could not develop MS. I think this is in line with how copax is now being given to many before the MS diagnosis - but for CIS.

I will start copax in 2 weeks...now looking forward to it....but, at least I know I am taking it for different reasons than when I was taking it just as a DMD.

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Postby mrhodes40 » Mon Jul 21, 2008 7:58 pm

MBP is not yet out, is it? That certainly might be at issue.

I have taken copaxone since it came out and progressed from jogging to edss 6. The heck of it was I was considered benign because I was 6years from diagnosis and still jogging. I went on cop and 11 years later here I am SPMS and a 6. I am frankly really unimpressed by the idea that copaxone will make a huge difference based on that experience, so if something else is possible to offer I'm all for it!

My MRI, BTW was inflammation and enhancement free. We're checking the spine now; I am thinking we might well find atrophy there, a hallmark of SPMS. I am not a good rev candidate, but will be keeping my ears to the ground for developments.
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Postby Cyclops » Tue Jul 22, 2008 12:08 am

The thing I like about MBP's approach is that it's aimed at secondary progressive.


My take on that is that its more of a marketing angle. Being first to market for SPMS will ensure market share. It would be a big step forward if it works for SPMS. They are doing trials for RRMS too. I think I read somewhere that interim data might be available soon.

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Re: MBP8298 vs Copaxone

Postby Lyon » Tue Jul 22, 2008 3:29 pm

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Last edited by Lyon on Sun Nov 27, 2011 3:11 pm, edited 1 time in total.
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Postby Lars » Wed Jul 23, 2008 6:18 pm

Forgive the layman's take on this but aren't Copaxone and MBP working on an similar Amino Acid theory. Reading the list of ingredients in Copaxone has led a Veterinary friend of mine to become convinced of the ease in reproducing it for pennies. Bear in mind....I know nothing!
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Postby Jamie » Wed Jul 23, 2008 7:04 pm

Bob said:

"That brings up another unknown about MBP8298, does it act as a vaccine by giving the immune system the false memory of having already fought this enemy? In this case it seems that this education of the naive immune system hinges on actually having experienced the battle and not simply being forewarned of the enemies weaknesses. "

I understand them as one and the same thing. Vaccines work by the body fighting a deactivated virus in very real battle, it's just it has time to figure out the correct weapon before the virus wins ('cos it is dead). That's how it learns.

Forearmed is literarily forewarned.
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Postby Lyon » Thu Jul 24, 2008 1:56 pm

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Postby chrishasms » Thu Mar 26, 2009 10:39 am

I just noticed this so here is a good answer for you. I actually learned this at a fund raiser meeting from one of the doctors in the study.

MBP8298 is actually an acronym for Myelin Basic Protein 82-98. It targets the specific proteins of Myelin. The doctor did say he was really interested to see the final results because there are other proteins in Myelin. The initial trial results did look really promising though.

I met Dr. Corboy there and asked him this question: "In my case they look at EDSS, relapse rates, and lesions with the HiCy trial. In SPMS with the MBP8298 what exactly is the end point if there is no inflammation?"

I was happy to hear that was a good question, lol, and he stated, "In this trial the end points are actually improvement in QOL and EDSS scores. "

If nothing else it shows some people out there are also using their noodles to stop or improve this disease rather than slowing it down.
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