So you are saying that the method of action of HiCy etc could be the massive anti-inflammatory power of the chemo rather than the immune system rebooting?
MS is not an autoimmune disease then yes. You can't tell what the caues of a disease is by the outcome of treatment, all you can know is whether it seemed to work or not. "Seemed to work" is good enough in this disease.
But, and I may be missing the point here, if the inflammation is caused by the immune system in the first place (regardless of what it originally reacted to) then isn't that the same thing?
for argument's sake lets pretend
for a minute that MS is that vein thing Zamboni is talking about; You have these stenoses and they cause reflux the reflux damages the brain tissue near the vein just like it does in the lower leg in the case of venous ulcers. Pretend.
So that process happens and the immune system comes along and starts trying to heal the damage. It ignites nitric oxide, adhesion molecules, MMP9 is upregulated and t cells and b cells rush in as part of the inflammation cascade to clean things up. This inflammation is damaging to the brain tissue in addition to any damage the initial reflux might have caused.
So if you knock out immunity so inflammation is not happening, then all that inflammatory damage can't happen. But to whatever degree the intial event can cause damage that damage will go on.
So in the example of mechanical injury from venous reflux, it would be some years before it became clear that some other process was going on if you figure that some portion of the damage is the inflammation itself and that part's been alleviated. Of course it is impossible to tell in this utter fantasy how much of the damage would be "inflammation" and how much would be "reflux".
My guess is that with good immune system suppression, since MS progresses slowly in the first place, it might be many years before it became clear something else is going on.
So in a way, yes, it could be considered as good, but best of all worlds is to find out what causes the immune system to activate (mechanical damage of reflux or........?) and fix THAT and do anti inflamatory measures if still needed.
I said I'd do it in a heartbeat and I meant it. I would perfectly happy sitting in my reboot and waiting for other things to play out.
I think it would be best if we had absolute proof of autoimmunity, in other words the actual antigenic target that is found in all MSers and confers human like MS (relapsing etc) on healthy animals if given to them. Or absolute proof of some other process that is causing the immune system to react (like the vein idea, or some germ or whatever), but barring that, using what works is just practical.
I'm glad you guys went for it!