Dosage?

A board to discuss Revimmune as a potential therapy for multiple sclerosis

Dosage?

Postby LR1234 » Mon Jul 13, 2009 8:15 am

What is the dosage given of the cyclophosphamide?
I found this article online and was wondering if the dosage is similar.

The objective of this case report is to document the possibility that immunoablative doses of cyclophosphamide may provide a long-term remission of multiple sclerosis (MS). We report the case of a 48-year-old woman with definite MS diagnosed in 1994 who has been in complete remission since a dose of 3800 mg of cyclophosphamide was accidentally given intravenously in early 1997. For 7 years there have been no signs of disease activity on history, physical examination, or on high-quality magnetic resonance imaging (MRI) with appropriate contrast-enhancement methodology.
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Postby Lyon » Mon Jul 13, 2009 1:34 pm

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Postby LR1234 » Mon Jul 13, 2009 1:37 pm

Thanks for the info Lyon

L
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Postby Lyon » Mon Jul 13, 2009 1:40 pm

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Postby LR1234 » Mon Jul 13, 2009 1:45 pm

It was an overdose at the time, I suppose because it was unintentional. I think maybe because they felt it worked they are adminstrating it now as a treatment at that dose.
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Postby Lyon » Mon Jul 13, 2009 2:07 pm

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Postby LR1234 » Mon Jul 13, 2009 2:37 pm

true, well if it turns how to stop the progression of MS I'm glad it happened! I was also looking for how many trials have been done on revimmune but I couldn't find any apart for the 20 or so patients treated at JH. I am in the UK so have contacted Accentia to see if any trials are being conducted here.
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Postby Lyon » Mon Jul 13, 2009 2:58 pm

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Postby chrishasms » Mon Jul 13, 2009 3:40 pm

That is the lady they thought they had killed and her MS went away and all the docs said, hey we are on to something.

The dose is 50 mg/kg of ideal body weight.
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Postby guitarguy » Mon Jul 13, 2009 4:02 pm

does anyone know how she is doing today?
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Postby chrishasms » Mon Jul 13, 2009 4:26 pm

From what I have heard just fine. I asked once and we just mentioned it in passing. She had cancer though so it may have come back who knows.
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Postby Axiom » Mon Jul 13, 2009 6:08 pm

Lyon wrote:
LR1234 wrote: To make matters even harder to keep track of, Dr Gladstone had been affiliated with JH at one time and then was doing HDC studies with Stonybrook. The JH research we're familiar with and evidently U of Chicago was/is/is going to do HDC research....as Revimmune?? I don't know.

I find it interesting by any name, but I wish I had a better grasp!

Bob



And for yet another wrinkle... Dr. Gladstone is back at JH
I don't know how involved he is with any MS trials though.


Chris,

Any idea why the dosage is calculated using ideal vs actual body weight?


FWIW, I admit I've gone with the ask forgiveness rather than permission paradigm more than once myself. :wink:
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Postby chrishasms » Mon Jul 13, 2009 8:42 pm

It's ideal body weight not actual body weight. The nurse was shocked because I was the first person who was exactly on the money. It's what you should weigh, not what you do.
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Re: Dosage

Postby NHE » Mon Jul 13, 2009 11:33 pm

Lyon wrote:I'm not good with math, but looking at the usual mg per kg, 3800 mg doesn't seem to be much of an "overdose"??


3800 mg would be about one day's worth of the Revimmune protocol. For a 150 lb. person they would receive about 3400 mg/day when being treated with Revimmune.

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Postby chrishasms » Tue Jul 14, 2009 5:57 am

That is a number actually that sounds really familiar actually NHE. Good call!
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