Never posted before! I've been on Rituxan for a little over two years. Initially, I received two doses (two weeks apart) per six months as others have stated. For the last year, I've had one infusion every 4 months. It has been very helpful for me as well - I was diagnosed in Sept 2002 and nothing has worked like this (previously tried Avonex, Copaxone, Avonex plus Copaxone, Tysabri, steroids, Gilenya, Tecfidera, IVIG). There are some side effects. With the infusion, i usually have high heart rate, elevated temperature and headaches. Occasionally during the infusion, I've had flushing, painful/itchy scalp, scratchy throat/coughing and difficulty catching my breath. I receive benedryl, Advil and steroids with the infusion, so it helps to cut down on this stuff. Also, if they run it very slow, that helps me tolerate it much better (the whole infusion can take up to 8 hours). Afterwards, I usually have a red, hot rash on the back of my arms for a few days, headaches and weakness for about a week. I usually have increased fatigue and prior symptom (mostly sensory) recurrence for about 2 weeks or so.