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Re: If have to discontinue Tysabri

Thanks to those who have replied. It looks like IRIS seems to be a problem only for those who had to discontinue Tysabri due to problems with PML. I noticed that the quote about IRIS was from 2004, so I wasn't sure if that information was still ...
by NHE
Mon Jun 11, 2018 11:25 pm
 
Forum: General Discussion
Topic: If have to discontinue Tysabri
Replies: 5
Views: 402

Re: If have to discontinue Tysabri

Thanks to those who have replied. It looks like IRIS seems to be a problem only for those who had to discontinue Tysabri due to problems with PML. I noticed that the quote about IRIS was from 2004, so I wasn't sure if that information was still relevant. ...
by odin1243
Mon Jun 11, 2018 11:35 am
 
Forum: General Discussion
Topic: If have to discontinue Tysabri
Replies: 5
Views: 402

Re: If have to discontinue Tysabri

While I haven't verified this, Biogen claims that IRIS has only been associated with cessation of Tysabri after PML has developed. If true, it may be best to stop Tysabri well before any PML symptoms become apparent. https://www.tysabrihcp.com/en_us/home/facts/risks-progression.html ...
by NHE
Sat Jun 09, 2018 1:42 am
 
Forum: General Discussion
Topic: If have to discontinue Tysabri
Replies: 5
Views: 402

Re: If have to discontinue Tysabri

... Have you had any difficulties? Hi Odin, I have no experience with Tysabri. However, stopping the drug has been associated with a condition called IRIS, or immune reconstitution inflammatory syndrome. I've linked to a few articles in the following post... http://www.thisisms.com/forum/tysabri-antegren-or-natalizumab-f11/topic22687.html#p212893
by NHE
Wed Jun 06, 2018 1:17 am
 
Forum: General Discussion
Topic: If have to discontinue Tysabri
Replies: 5
Views: 402

Re: Has anyone else tried clemastine fumarate @ new relapse?

... results given? noticing this in passing http://www.pathguy.com/lectures/wilsons.gif re eye doc is it just presence absence of the ring around the iris? or other stuff too? what was the gastro's deal? "Neurologist says I must magically have lesions in perfect layout and position to mimic giant ...
by jimmylegs
Fri Jan 05, 2018 12:06 pm
 
Forum: General Discussion
Topic: Has anyone else tried clemastine fumarate @ new relapse?
Replies: 32
Views: 1737

Again: Something unknown in CSF is neurotoxic.

Effect of extracellular vesicles from CSF of multiple sclerosis patients and healthy controls on astrocytes in culture https://iris.unipa.it/handle/10447/249624?mode=full.194 INTRODUCTION Secretion of extracellular vesicles (EVs) and EV-mediated exchange of molecules among brain cells, ...
by frodo
Sun Dec 17, 2017 12:48 pm
 
Forum: MS Etiology and Pathogenesis
Topic: Again: Something unknown in CSF is neurotoxic.
Replies: 0
Views: 681

Re: Hi Friends *waves shyly*

... body weight per day? what's your daily dietary intake in mgs? what's the typical daily add via supplementation? good read: http://apps.who.int/iris/bitstream/10665/43836/1/9789241563550_eng.pdf excerpt: "Lowenstein and Stanton (1986) established the reference interval (central 95th percentile) ...
by THX1138
Sun Oct 29, 2017 5:05 pm
 
Forum: Introductions
Topic: Hi Friends *waves shyly*
Replies: 23
Views: 1992

Re: Hi Friends *waves shyly*

... body weight per day? what's your daily dietary intake in mgs? what's the typical daily add via supplementation? good read: http://apps.who.int/iris/bitstream/10665/43836/1/9789241563550_eng.pdf excerpt: "Lowenstein and Stanton (1986) established the reference interval (central 95th percentile) ...
by THX1138
Sun Oct 29, 2017 5:03 pm
 
Forum: Introductions
Topic: Hi Friends *waves shyly*
Replies: 23
Views: 1992

Re: Hi Friends *waves shyly*

... body weight per day? what's your daily dietary intake in mgs? what's the typical daily add via supplementation? good read: http://apps.who.int/iris/bitstream/10665/43836/1/9789241563550_eng.pdf excerpt: "Lowenstein and Stanton (1986) established the reference interval (central 95th percentile) ...
by jimmylegs
Sun Oct 29, 2017 6:09 am
 
Forum: Introductions
Topic: Hi Friends *waves shyly*
Replies: 23
Views: 1992

Re: My expierence with Coimbra protocol

... neuro left. I just could find a replacement :( I upped my D immediately. I knew the importance. I ran across the Coimbra Protocol a few days back. IRIS and rebound are (the same but different) IRIS is after PML. I don't have PML. I do however have rebound. It's all dr jib jab for sick sick sick. .
by Izzy00
Mon Jun 26, 2017 3:22 pm
 
Forum: Coimbra High-Dose Vitamin D Protocol
Topic: My expierence with Coimbra protocol
Replies: 17
Views: 5041

Re: My expierence with Coimbra protocol

... nearly 3 months. It may be wise to ask for a round of IV methylprednisolone. Here's what Tysabri's prescribing information has to say about IRIS. https://www.tysabri.com/content/dam/commercial/multiple-sclerosis/tysabri/pat/en_us/pdfs/tysabri_prescribing_information.pdf Immune reconstitution ...
by NHE
Mon Jun 26, 2017 1:15 pm
 
Forum: Coimbra High-Dose Vitamin D Protocol
Topic: My expierence with Coimbra protocol
Replies: 17
Views: 5041

Re: My expierence with Coimbra protocol

... this rebound nor had time. I know it will not most probably.This is a serious event. Yes, if you have immune reconstitution inflammatory syndrome (IRIS), then you should seek treatment for that ASAP. Lethal Multiple Sclerosis Relapse After Natalizumab Withdrawal Neurology. 2012 Oct 24. [Epub ahead ...
by NHE
Mon Jun 26, 2017 9:55 am
 
Forum: Coimbra High-Dose Vitamin D Protocol
Topic: My expierence with Coimbra protocol
Replies: 17
Views: 5041

Re: Hello

... try to find the related resource i am thinking of. in the meantime if you have not seen this, it's got loads of good info: http://apps.who.int/iris/bitstream/10665/43836/1/9789241563550_eng.pdf (can't guarantee i agree with 100% of content. part of the reason why i chose the image i did for ...
by jimmylegs
Thu Apr 20, 2017 9:15 am
 
Forum: Introductions
Topic: Hello
Replies: 252
Views: 15634

Re: Confusion, hesitancy, ms

I am a 23 years old university student, since i was 20 my eyes got red with a gray scale near my iris(like uveitis) from time to time. None of the 4 eye doctors i visited could diagnose my disease, they just told me it was probably allergic and eye drops they gave to me ...
by qweqwe1
Tue Jul 26, 2016 12:53 pm
 
Forum: General Discussion
Topic: Confusion, hesitancy, ms
Replies: 6
Views: 710

Re: Confusion, hesitancy, ms

I am a 23 years old university student, since i was 20 my eyes got red with a gray scale near my iris(like uveitis) from time to time. None of the 4 eye doctors i visited could diagnose my disease, they just told me it was probably allergic and eye drops they gave to me ...
by lyndacarol
Mon Jul 25, 2016 12:57 pm
 
Forum: General Discussion
Topic: Confusion, hesitancy, ms
Replies: 6
Views: 710
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