Statins have detrimental effects on remyelination in MS

Discussion of statins (Lipitor, Zocor, etc.) in the treatment of MS.

Statins have detrimental effects on remyelination in MS

Postby MSUK » Fri Sep 24, 2010 12:26 am

Image

Simvastatin interferes with process outgrowth and branching of oligodendrocytes.

Abstract

Statins have attracted interest as a treatment option for multiple sclerosis (MS) because of their pleiotropic antiinflammatory and immunomodulatory effects.

However, contradictory results have been described when they are applied to oligodendrocytes (OLGs), the cell type predominantly affected in MS. In this study we focus on the in vitro effect of statins on process outgrowth in OLN-93 cells, a well-characterized OLG-derived cell line, and primary cultures of neonatal rat OLGs. ... Read More - http://www.msrc.co.uk/index.cfm/fuseact ... ageid/1319
MS-UK - http://www.ms-uk.org/
User avatar
MSUK
Family Elder
 
Posts: 2225
Joined: Wed Oct 14, 2009 2:00 pm

Advertisement

Return to Statins

 


  • Related topics
    Replies
    Views
    Last post

Who is online

Users browsing this forum: No registered users


Contact us | Terms of Service