Allo-HSCT: Doesn't Stop Inflam or Demyelination

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Allo-HSCT: Doesn't Stop Inflam or Demyelination

Postby Shayk » Sat Jun 19, 2010 4:04 pm

Here's an interesting abstract that popped up on Pub Med today.

Neuroinflammation and demyelination in multiple sclerosis after allogeneic hematopoietic stem cell transplantation
RESULTS: Demyelinating and inflammatory activities of MS persisted after allo-HSCT in all of the patients with MS.

CONCLUSION: Allo-HSCT fails to halt the demyelination and inflammation of MS


Maybe that will be the end of that.

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Postby rainer » Sat Jun 19, 2010 7:35 pm

I wouldn't expect a study with 4 MS patients who died 4.5 months after the transplant to be the definitive answer on much of anything.

. The normal-appearing brains of allo-HSCT recipients who did not have MS were found to have significantly higher numbers of CD3(+) T cells and CD8(+) cytotoxic T cells and higher scores of CD68(+) microglia/macrophages compared with the controls; however, no demyelination was identified in these non-MS samples.


Also interesting that they found neural inflammation in the non-ms patients who had the procedure.
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Re: Allo-HSCT: Doesn't Stop Inflam or Demyelination

Postby mmonica » Sun Jun 20, 2010 4:22 pm

Shayk wrote:
Maybe that will be the end of that.

Sharon



I hope not, this study isnt enough to prove anything.....


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Postby mmonica » Tue Jun 22, 2010 3:48 pm

http://msj.sagepub.com/cgi/content/abstract/16/6/685

I dont hope this is the end of that. I hope it continues conversations, research and debate
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