packo wrote:Today I visited my neurologist just for a control check-up. It appears that my EDSS (when we take into account that due to the fracture my left leg is 3cm shorter so this adds to my disability, but directly has nothing to do with MS) right now is 4.0, and prior to transplant was 6,6.5.
One additional information about the protocol I received at Hadassah, the non-myeloablative regimen included fludarabine (30mg/m2 ) intravenously (i.v.) once daily for four consecutive days from day -6 to day -3, cyclophosphamide (50mg/m2) i.v. once daily for two consecutive days from day -5 to day -4 and Campath (0.25mg/kg) i.v. once daily for two consecutive days from day -2 to day -1.
Awesome news on the EDSS improvement Packo. Congrats! I always love hearing about people's improving (MS) health.
My own EDSS started (pre-transplant) at 3.5 and now (16 months post-transplant) I'm a solid EDSS 2.0. Mathematically that's a 42% improvement for me. And for you its nearly a 40% improvement. Very similar magnitude effect.
And thanks for the detail on the chemical protocol. I think both Fludarabine and Campath are good pairing with the Cyclophosphamide. All are strongly lymphoablative (which should be the target), and less myeloablative (allowing for a more prompt recovery timeframe).
Again, great to hear about your improving health. And good luck & best wishes for a quick recovery with the leg fracture.