HSCT has long been one of my strong interests and I was your results with hope and interest....I have no interest in seeming insulting but curiosity compels that I ask, what exactly is your definition of the word "cure"?
Absolutely no offense taken. And a very valid and fair question. . . .
Since there is no universal definition of what "cure" means (not even amoung doctors), it is up to each individual to decide for themselves what a cure is. As for me the definition was the same as my original objective. . . . "To stop or halt the underlying disease activity and completely stop the progression of my dease." This happens in virtually 100% of HSCT-treated RRMS patients, about 80% of SPMS patients (me) and about 65% of advanced (non ambulatory) PPMS patients.
But I also understand that some people will not accept this definition of a cure. Many people will want to see significant "improvement" or "reversal" of their symptomatic status. This usally happens in greater than >80% of RRMS patients, greater than approximately >65% of SPMS patients (me) but is unfortunately unlikely to occur to a substantial degree in advanced (non-ambulatory) PPMS patients. So I was EDSS 3.5 at the time of my HSCT. And today at 16 months post-transplant I am at (nearly) 2.0 EDSS. So luckily for me I have also experienced substantial improvement of my pre-existing symptoms (but not 100% reversal, which is unlikely to occur).
Scientists Reverse Early MS With Patients' Own Stem Cells
"After an average follow-up of three years after receiving their transplants (which took place between January 2003 and February 2005), 17 patients (81 per cent) improved by at least one point on a [EDSS] disability scale. And for all [100%] patients, the disease had stopped progressing."
Here is a graph I put together (from the various phase I and phase II clinical trial data) indicating the relative probability of these two (stopping and/or reversing) curative phenomenon based on MS disease status at time of HSCT:
http://2.bp.blogspot.com/-PvejGH-NIG4/T ... al%2B2.jpg
And as much of a quantitative explanation as I could to describe the improvement status at one year post-transplant (and today at 16 months I'm a little better than as described here):
http://themscure.blogspot.com/2010/12/1 ... tatus.html
So it is up to each individual to decide if this constitues a cure. But for me it is because now my disease progression is 100% stopped with absolutely no new or added deficit and no new (MRI) lesion activity, all (every single one of) my symptoms have improved and a substantial degree of certaintly for my future health has been restored (makes planning for the future more possible). Basically, before HSCT I was headed toward a wheelchair and today I am definitely moving further away from ever needing a wheelchair.