This what I wrote someone, only reflecting my humble opinion formed by what I read, experienced and heared from professionals: "SPMS is a turning point where MS turns into a different disease. Chances HSCT will make a difference in a disease with no inflammation are slim. Specifically, HSCT has proven most effective in stopping and to an extent reversing MS for people with active and aggressive MS. If you have active MS and I were you, I would waste no time and do HSCT while bearing in mind there are no guarantees, always hoping for the best and preparing for the worst.
HSCT is thus a means to halt an active disease. Potential reversal of symptoms is a secondary benefit as your nerves are no longer under constant barrage allowing for autonomous recovery. If you want to engage in damage repair Msc's is the best game in town, again no guarantees.
So, the right sequence for you would be first HSCT, followed by Msc's. I any event, always seek treatment from reputable experts. You wouldn't buy a car from a non certified dealer would you? Lo and behold when it comes to treating your MS. Prof. Slavin in Tel Aviv is one of the, if not the best in his field.
Asher wrote:So here is the promised status report, but first the facts:
• In day +5 my white cell count dropped to 0.0035, indicating my immune system was practically eradicated
• Day +6 was 0.03
• Day +7 was 4.5
• Day +8 was 35
• And today, day +9 was 130
Professor Dr. Ho, the amazing gentleman who runs the stem cell transplantation ward of the Heidelberg university hospital told me this morning that he expects the count will exceed 1000 in the next 48 hours. Thereafter my new immune system will rapidly recover to normal levels (varies by individual, anywhere between 4000 and 10,000).
Now when you ask an MS patient who is undergoing HSTC to describe how they are doing, one must realize that there are 4 distinct phases.
Asher wrote:- Whilst an immune response has been proven beyond doubt to play a role in MS, there is growing evidence that it can not explain the whole picture. Moreover, a growing number of scientists believe that the immune response is indeed exactly that; an 'immune response' to something else that is going on. This may help explain why HSCT does not work for everyone. MS remains an enigma.
This is not only growing, but I would say, it is well known. At CTCI, they DO NOT recommend HSCT if you do not have active lesions and if there is no significant differences in MRIs. You are fully right that MS is an enigma and it is really good that you drew attentions to these things that patients usually forget.
What is interesting that someone might have no active lesions when he has the progressive form of the disease and his MRIs show no differences in let's say ten, fifteen years, but his condition is still deteriorating. This is quite typical. Also think about it, DMDs that modify the immune responses DO NOT help in most progressive cases and they do not halt progression at all.
That is for sure that there is an autoimmunity component of the disease as you said, but it seems that autoimmunity can not explain the whole picture, mainly the progression phase. I think that should have been already clear when DMDs could not halt progression.
Asher wrote:I'm not a scientist but my common sense tells me there is a difference between inflammation (RR) and degeneration SP & PP although loss of gray mass e indicates there is also a degenerative component early on in the disease). What causes both no one really knows... The immune theory alone can not explain the whole picture.
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