My CtrlAltDel - Status

Discuss stem cells, adult and embryonic, and their therapeutic potential for MS here.

Re: My CtrlAltDel - Status

Postby Asher » Thu Sep 12, 2013 5:36 am

26 months since HSCT and 9 moths post MSC transplantation. Apart for my right leg that has somewhat declined since HSCT, overall I can report that I am now stable and feeling reasonably good.

http://www.medicalnewstoday.com/releases/265884.php
http://www.stemcellresearchnews.com/abs ... a=3220&z=9
http://www.stemcellresearchnews.com/abs ... a=3223&z=9
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Re: My CtrlAltDel - Status

Postby bspotts1 » Mon Sep 16, 2013 5:05 am

Hi Asher,

Thanks for the post...glad you are stable and feeling well. Since your MSC procedure have you noticed any improvements in any of your symptoms??? Stability is great but in the end we all hope for some / any kind of improvement...pie-in-the-sky.

brad in sarasota
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Re: My CtrlAltDel - Status

Postby Asher » Tue Sep 17, 2013 9:23 am

I sincerily hope/believe that differentiated 'neural stem cells' and improved delivery methods that get the stem cells to an area that needs to be fixed will do the trick.
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Re: My CtrlAltDel - Status

Postby shaight » Mon Oct 14, 2013 9:30 am

Asher, glad to hear you are feeling 'reasonably good'. Best moving forward
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Re: My CtrlAltDel - Status

Postby Asher » Fri Oct 25, 2013 11:54 am

This is what I was talking about; scientists making progress that makes regenerative stem cell therapy look more feasible than ever:


New way to grow neural stem cells may accelerate therapy development for brain injuries and disease

Monday 14 October 2013 - 2am PST

Stem Cell ResearchNeurology / Neuroscienceemailprint

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New way to grow neural stem cells may accelerate therapy development for brain injuries and disease
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Researchers have discovered a new, highly efficient way to produce neural stem cells from human pluripotent stem cells that can then go on to form neurons in the brain. The discovery, reported in the current issue of STEM CELLS Translational Medicine, could greatly accelerate the development of new drug and cell therapies for people suffering from brain injuries or disease.

Human pluripotent stem cells (hPSCs), including human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs), show great promise in regenerative medicine due to their ability to be "coaxed" into becoming different specific types of cells. These cells can theoretically then go on to help the body heal itself by replacing or repairing damaged or dead cells.

However, the current methods for inducing neural stem cells involve time-consuming, multiple labor-intensive steps that cannot be easily automated or made GMP (good manufacturing practice) compliant for clinical grade manufacture. In addition, not many of the neural stem cells produced this way can be expanded and coaxed into becoming different neural subtypes specific to the brain regions responsible for controlling different functions.

"Towards this critical need, we have developed a simple one-step protocol with a GMP-manufactured medium that is rapid and efficient in the derivation of neural stem cells (from hPSCs) that retain the cues to differentiate into different disease relevant neurons. By starting with a million pluripotent stem cells, it is possible to get approximately 40 to 50 million neural stem cells in seven days," said Mohan C. Vemuri, Ph.D., director of research and development for Cell Biology and Stem Cell Systems at Life Technologies, Frederick, Md. He was lead author of the study done in conjunction with researchers from Buck Institute for Age Research, Novato, Calif., the Methodist Hospital Research Institute in Houston and the National Institutes of Health, Bethesda, MD.

"This method sets the stage for producing neural cells that potentially could lead to new therapies for diseases such as Parkinson's," he added.

"Whether the intended use is drug discovery or cell therapies for neurologic diseases, it is essential to develop efficient and reproducible differentiation methods for neurons," said Anthony Atala, M.D., editor of STEM CELLS Translational Medicine and director of the Wake Forest Institute for Regenerative Medicine. "This study reports on a new method for the robust and reproducible production of neural stem cells."

http://www.medicalnewstoday.com/releases/267342.php
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Re: My CtrlAltDel - Status

Postby Asher » Fri Nov 08, 2013 7:12 am

http://www.stemcellresearchnews.com/abs ... a=3260&z=9

But you see, it will take some time before this technology is ripe for therapeutic purposes.
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Re: My CtrlAltDel - Status

Postby Asher » Mon May 26, 2014 6:43 am

Hi, in response to the following PM:

I was wondering how you were doing post-HSCT? Are you in remission or have you relapsed?

Interesting to observe that there may be 2 different MS mechanisms at play: On the upside, the inflammatory character of my MS has vanished. Impaired speech, swallowing, fatigue and optic nerve symptoms are either markedly reduced of vanished altogether. On the downside, macular atrophy and motor impairment of my right leg and arm have continued well after HSCT, albeit art a slow(er) rate.

I am waiting for regenerative medicine to fix these issues. Optimism is true moral courage.
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Re: My CtrlAltDel - Status

Postby miri » Thu Jul 17, 2014 2:40 pm

Asher wrote:Hi, in response to the following PM:

I was wondering how you were doing post-HSCT? Are you in remission or have you relapsed?

Interesting to observe that there may be 2 different MS mechanisms at play: On the upside, the inflammatory character of my MS has vanished. Impaired speech, swallowing, fatigue and optic nerve symptoms are either markedly reduced of vanished altogether. On the downside, macular atrophy and motor impairment of my right leg and arm have continued well after HSCT, albeit art a slow(er) rate.

I am waiting for regenerative medicine to fix these issues. Optimism is true moral courage.

That's why it's important for people to ask more of the following question:

Attn: Stem-Cell Doctor:
(1) What is your approach toward overcoming the factor of aging pathways (Notch/pSmad)
(2) What is your approach to detox prior to cell infusion?
Is your approach - radical chemo? Plasmapheresis?
Or alternatively, non-invasive, yet-effective InfraMud Detox?
Image
Reachable via PM. Seems I have Higbee's HSII on ThisIsMS. Frustrated by MSers, FMers, Lymers & Prematurely-Aged-By-EMFers who prefer cryptic jargonian Systems Vs. Intuitive empirical experience. Don't simple truths count for anything anymore?
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