Neurologists told me that currently they believe that in spms and ppms autoimmunity is not the primary culprit, eventhogh if it is there. Probably, this is the reason why they do not give any immunmodulatory drugs for ppms patients.
I often hear this a lot on this site. But lets look at a Nueron:
So in RRMS the main target is the Myelen sheath (white matter) while there may be some secondary damage to the axons. The white matter damage is what shows up on MRI's as lesions.
In SPMS and PPMS the main damage is to axons (grey matter).
So, my question is that if either type of MS is not autoimune why are not the other structures of the neuron such as the cell body (soma) effected. Why is it that only specific areas of the neuron are targets?
Hi CV Factor,
Here's one more clarification. Your diagram appears to be of the peripheral nerves and not nerves of the central nervous system. I post about this all the time, because I've been diagnosed with both MS and HNPP, a hereditary peripheral neuropathy. Schwann cells
are for the PNS and not the CNS (those are oligodendrocytes
I'll post a bit of info from other threads, but if it's not clear, I can add more, because I write about PNS vs CNS all the time.
Glial cells thread from Squiffy:general-discussion-f1/topic9065.html?hilit=schwann
And the MSRC article link in that thread:http://www.msrc.co.uk/index.cfm?fuseact ... ageid=1398
Explanation about glial cells from that article:
Glial cells serve nerve cells by insulating them with layers of fats and proteins called myelin. Myelin coatings are necessary for nerve signals to be transmitted normally; when the sheaths are lost, disorders involving impairment in sensation, movement and cognition such as multiple sclerosis or amyotrophic lateral sclerosis develop. Glial cells named oligodendrocytes produce myelin around nerves of the central nervous system, while those named Schwann cells make myelin that insulates peripheral nerves.
And for the sake of explaining why I pay so much attention to these cells, here's a quote from one of the threads where I explained the difference in my case.
A quote from me on that thread:
I'm still not sure if there's any sort of connection between MS & HNPP, although my family's situation raises intriguing questions.
HNPP means that MY peripheral nerves are unable to handle physical stress to them due to a missing myelin gene. Some other "named" peripheral neuropathies, such as CIDP, sound more like inflammation caused by other reasons, such as viruses, etc.
Also, just for the sake of background information in this discussion, I should have mentioned that the myelin in the CNS (brain & spinal cord) is made up of oligodendrocytes, whereas the myelin covering of the peripheral nerves (all other nerves in the body) is from Schwann cells instead.
So, my LP shows that I have both O-bands in my spinal fluid (plus whatever else they look for) and the extensive round of EMGs they gave me (I call it The Day of the Long Needles ) show I have carpal tunnel in both wrists & both elbows (at least). That's what puts the PP (Pressure Palsies) into HNPP. (I also have a brain that's Chock Full O' MS-specific Lesions, but who's counting at this point?)
My cousin with MS has had 2 unsuccessful carpal tunnel surgeries (possible HNPP), although my dad had a recent MRI of his brain showing only that he had, well, a "normal" 87-year-old brain. My dad, cousin, and I have footdrop, but my neuros shrug that there's no way to figure out whether my footdrop & hand tremors are due to MS or HNPP or both.
Also, FYI - both the "named" PNs like CIDP & HNPP and also the generic, unnamed PN condition can show remarkably similar symptoms to MS. Just check out the generic PN pages at Mayo: http://www.mayoclinic.com/health/periph
The term "peripheral neuropathy" in general just refers to a group of symptoms within the PNS, which includes the sensory nerves, muscles, and organs, affecting things like bowel & bladder issues as well. PN can be the result of genetics (me), diseases, vitamin deficiencies, etc., which is why I always feel obligated to remind undx'd sufferers (who don't test as well as I do ) of the possibilities.
Another note: HNPP is a malfunction of the same gene (missing part) as CMT, Charcot-Marie-Tooth (doubled gene), a much more common hereditary neuropathy. They're often mentioned together when you do research.
Now, wasn't it nice to have a short break from discussing only stem cells?