I'm especially interested in HSCT and PPMS because I am currently a suspected PPMS patient and, at 20 years old and my whole life ahead of me, I am determined to stop at nothing to prevent further progression. So far I am EDSS 2.0 and my physician suspects I may have had PPMS for years.
I found this 2009 Russian study which, in a rare break from the clinical obsession with RRMS patients, included a sizeable portion of PPMS patients in a trial of HSCT treatment efficacy under three protocols: early intervention to halt progression, medium intervention to limit damage and prevent further deterioration, and late-stage or "salvage" intervention to try and prevent death from severe progression. There was one case where a severely disabled EDSS 7 PPMS patient had recovered to an EDSS score of 6 at 3.5 years followup. Also, early intervention in all cases appeared to yield higher results.
It's an encouraging study as there has almost been a disdain towards PPMS patients seeking HSCT treatment. Sort of a 'wait your turn' attitude which is profoundly disheartening, especially as the PPMS course is otherwise so difficult to treat and yields no chance of respite.
Here is the link: http://www.stemcellms.ru/doklad06.php
Thanks for posting this Mike! I had always known from early US-based (phase I) clinical trial data that PPMS patients, on balance, had beneficial efficacy with HSCT. But this is the first time I have seen this Russian study that you have cited and I appreciated being able to read through it which provides a greater level of detailed clinical results.
I think the clear lesson here is that people with all forms of MS have an opportunity to experience probable curative benefit with HSCT (better than any other treatment available today). And it's also very clear that treatment earlier, as opposed to later is better.