MS bone marrow stem cell trial to begin

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MS bone marrow stem cell trial to begin

Postby MSUK » Mon Dec 05, 2011 3:55 am

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British doctors are to conduct a trial using bone marrow stem cells that they hope could halt or perhaps even reverse the progression of multiple sclerosis (MS).

The Bristol University team wants to recruit 80 people for the research, after a pilot study in six people showed "tantalising" results.

The technique involves harvesting bone marrow from the patient, filtering out the stem cells and then injecting them into the person's veins the same day.

The theory is that the stem cells help repair damage caused to the protective coating of nerve cells, called myelin, which is the cause of MS.... Read More - http://www.msrc.co.uk/index.cfm/fuseact ... ageid/1405
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Re: MS bone marrow stem cell trial to begin

Postby Asher » Mon Dec 05, 2011 5:17 am

Sorry squiffy2 for this critical note, and no offense meant, but the reporter has gotten the concepts of "repair, halt, reverse" all mixed up. Repairing damage is a whole different concept to halting progression. I can hardly see how "halt" can happen without fixing the underlying issue of immune intolerance. Besides, "4 patients" sounds hardly convincing to me. Were they RR patients? If so, how can we tell placebo from spontaneous remission or the working of the stem cells. I'm not saying it is, but it sounds a bit like some of the anecdotal CCSVI stories which are often confused for scientific fact.
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Re: MS bone marrow stem cell trial to begin

Postby MSUK » Mon Dec 05, 2011 5:24 am

Hi Asher, this is the press we are talking about :-D

Here is the report on the first study which has led to this new one

Bone-marrow stem cell study in MS shows promising results
A groundbreaking trial to test bone marrow stem cell therapy with a small group of patients with multiple sclerosis (MS) has been shown to have possible benefits for the treatment of the disease.

Bone marrow stem cells have been shown in several experimental studies to have beneficial effects in disease models of MS. The research team, led by Neil Scolding, Burden Professor of Clinical Neurosciences for the University of Bristol and North Bristol NHS Trust, have now completed a small trial in patients with MS to begin translating these findings from the laboratory to the clinic.

The Bristol team report on this pioneering trial in an article published online in Clinical Pharmacology and Therapeutics. The paper, 'Safety and feasibility of autologous bone marrow cellular therapy in relapsing-progressive multiple sclerosis' was performed at the Institute of Clinical Neurosciences, Frenchay Hospital, Bristol and the Bristol Haematology and Oncology Centre.

The study explored the safety and feasibility of cell therapy in patients with MS. Participants had a general anaesthetic during which bone marrow was harvested. The marrow cells were filtered and prepared so that they could be injected into the patient's vein later the same day.

The procedure was well tolerated and the participants were followed up for a year. No serious adverse effects were encountered. The results of clinical scores were consistent with stable disease. The results of neurophysiological tests raised the possibility of benefit.

Professor Neil Scolding said: "We are encouraged by the results of this early study. The safety data are reassuring and the suggestion of benefit tantalising. A larger study is required to assess the effectiveness of bone marrow cellular therapy in treating MS. We are hopeful that recruitment to this phase 2/3 study may begin towards the end of this year.

"Research into the underlying mechanisms is ongoing and vital, in order to build on these results. We believe that stem cells mobilised from the marrow to the blood are responsible, and that they help improve disease in several ways, including neuroprotection and immune modulation."

The aim of the trial was to find out what effects, good or bad, bone marrow stem cells has on patients with MS, and their disability.

Bone marrow is known to contain stem cells capable of replacing cells in many types of tissues and organs - and so is of great interest to those working to develop new treatments for many diseases, including those affecting the nervous system.

The study has been funded by the Adrian Wright Bequest, The Patrick Berthoud Charitable Trust, the Silverman Family Foundation, The Myelin Project, the Captain SK Trust and The Burden Trust.

Source: Eureka! Alert (06/05/10)
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Re: MS bone marrow stem cell trial to begin

Postby Asher » Mon Dec 05, 2011 7:29 am

Thank you, this sounds more like it. So much for journalism :lol:
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Re: MS bone marrow stem cell trial to begin

Postby MSUK » Mon Dec 05, 2011 7:40 am

I couldn't possibly comment :lol: :lol:
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