Stem Cell Transplant Trial Yields Positive Results For MS

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Stem Cell Transplant Trial Yields Positive Results For MS

Postby seeva » Tue Jan 16, 2018 12:46 am

HI FRIENDS PLEASE READ

Trial Of Stem Cell Transplants Yields Positive Results For Patients With MS
http://ushealthtimes.com/trial-of-stem- ... s-with-ms/

regards
seeva
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Re: Stem Cell Transplant Trial Yields Positive Results For M

Postby NHE » Wed Jan 17, 2018 12:15 am

High-Dose Immunosuppressive Therapy and Autologous Hematopoietic Cell Transplantation for Relapsing-Remitting Multiple Sclerosis (HALT-MS) A 3-Year Interim Report
https://jamanetwork.com/journals/jamane ... le/2084840

Importance: Most patients with relapsing-remitting (RR) multiple sclerosis (MS) who receive approved disease-modifying therapies experience breakthrough disease and accumulate neurologic disability. High-dose immunosuppressive therapy (HDIT) with autologous hematopoietic cell transplant (HCT) may, in contrast, induce sustained remissions in early MS.

Objective: To evaluate the safety, efficacy, and durability of MS disease stabilization through 3 years after HDIT/HCT.

Design, Setting, and Participants: Hematopoietic Cell Transplantation for Relapsing-Remitting Multiple Sclerosis (HALT-MS) is an ongoing, multicenter, single-arm, phase 2 clinical trial of HDIT/HCT for patients with RRMS who experienced relapses with loss of neurologic function while receiving disease-modifying therapies during the 18 months before enrolling. Participants are evaluated through 5 years after HCT. This report is a prespecified, 3-year interim analysis of the trial. Thirty-six patients with RRMS from referral centers were screened; 25 were enrolled.

Interventions: Autologous peripheral blood stem cell grafts were CD34+ selected; the participants then received high-dose treatment with carmustine, etoposide, cytarabine, and melphalan as well as rabbit antithymocyte globulin before autologous HCT.

Main Outcomes and Measures: The primary end point of HALT-MS is event-free survival defined as survival without death or disease activity from any one of the following outcomes: (1) confirmed loss of neurologic function, (2) clinical relapse, or (3) new lesions observed on magnetic resonance imaging. Toxic effects are reported using National Cancer Institute Common Terminology Criteria for Adverse Events.

Results: Grafts were collected from 25 patients, and 24 of these individuals received HDIT/HCT. The median follow-up period was 186 weeks (interquartile range, 176-250) weeks). Overall event-free survival was 78.4% (90% CI, 60.1%-89.0%) at 3 years. Progression-free survival and clinical relapse-free survival were 90.9% (90% CI, 73.7%-97.1%) and 86.3% (90% CI, 68.1%-94.5%), respectively, at 3 years. Adverse events were consistent with expected toxic effects associated with HDIT/HCT, and no acute treatment-related neurologic adverse events were observed. Improvements were noted in neurologic disability, quality-of-life, and functional scores.

Conclusions and Relevance: At 3 years, HDIT/HCT without maintenance therapy was effective for inducing sustained remission of active RRMS and was associated with improvements in neurologic function. Treatment was associated with few serious early complications or unexpected adverse events.
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Re: Stem Cell Transplant Trial Yields Positive Results For M

Postby ElliotB » Wed Jan 17, 2018 5:17 am

Fake News!

"sustained remissions in early MS"

This is a normal condition for most of those with early MS! Virtually all protocols make the same claim for the same reason.

In fact, there are many, many studies which indicate that stem cell therapy is ineffective.



And finally:

"Almost 80% of participants survived without experiencing any increase in disability or relapse of clinical symptoms, meaning that most remained in remission"

Well, about 80% of those with MS, without doing anything , have the same result.

The 80/20 rule applies to pretty much ALL MS treatments:

"The Pareto principle (also known as the 80/20 rule, the law of the vital few, or the principle of factor sparsity) states that, for many events, roughly 80% of the effects come from 20% of the causes"

A real world example, the Swank Diet had an approximately 80% success rate. not really any better statically than those who don't do anything special in their lives.
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Re: Stem Cell Transplant Trial Yields Positive Results For M

Postby Pesho » Wed Jan 17, 2018 12:42 pm

ElliotB wrote:Fake News!

"sustained remissions in early MS"

This is a normal condition for most of those with early MS! Virtually all protocols make the same claim for the same reason.

In fact, there are many, many studies which indicate that stem cell therapy is ineffective.



And finally:

"Almost 80% of participants survived without experiencing any increase in disability or relapse of clinical symptoms, meaning that most remained in remission"

Well, about 80% of those with MS, without doing anything , have the same result.

The 80/20 rule applies to pretty much ALL MS treatments:

"The Pareto principle (also known as the 80/20 rule, the law of the vital few, or the principle of factor sparsity) states that, for many events, roughly 80% of the effects come from 20% of the causes"

A real world example, the Swank Diet had an approximately 80% success rate. not really any better statically than those who don't do anything special in their lives.

Please show something that is having more than 80% success rate?
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Re: Stem Cell Transplant Trial Yields Positive Results For M

Postby ElliotB » Wed Jan 17, 2018 12:53 pm

"Please show something that is having more than 80% success rate?"

That is exactly my point, there really isn't anything higher, as around 70%-80% of those with MS typically do well without any intervention of any kind and that is typically the success rate reported for virtually ALL the successful interventions. SO the conclusion of this study is basically no different from those with MS in the general population without treatment: "Almost 80% of participants survived without experiencing any increase in disability or relapse of clinical symptoms, meaning that most remained in remission." " Most with MS don't have many if any relapses in the years just after diagnosis.

Keep in mind that the conclusions made in this study were based on 25 individuals over a 3-year period. I know a couple of people who have gone about 10 years without a relapse and don't take any medication or follow any special diet.

Also keep in mind that there are many dangers associated with Stem Cell Therapy, including death!
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Re: Stem Cell Transplant Trial Yields Positive Results For M

Postby Pesho » Sun Jan 21, 2018 12:37 pm

ElliotB wrote:"Please show something that is having more than 80% success rate?"

That is exactly my point, there really isn't anything higher, as around 70%-80% of those with MS typically do well without any intervention of any kind and that is typically the success rate reported for virtually ALL the successful interventions. SO the conclusion of this study is basically no different from those with MS in the general population without treatment: "Almost 80% of participants survived without experiencing any increase in disability or relapse of clinical symptoms, meaning that most remained in remission." " Most with MS don't have many if any relapses in the years just after diagnosis.

Keep in mind that the conclusions made in this study were based on 25 individuals over a 3-year period. I know a couple of people who have gone about 10 years without a relapse and don't take any medication or follow any special diet.

Also keep in mind that there are many dangers associated with Stem Cell Therapy, including death!

So your point is that all current treatments are fake? HSCT is the only treatment that is reversing the disability and some people even walked after it. There are many dangers will ALL current medications, death being one of them as well.
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Re: Stem Cell Transplant Trial Yields Positive Results For M

Postby ElliotB » Sun Jan 21, 2018 1:53 pm

"So your point is that all current treatments are fake?"

In simple terms, yes. While it is thought that they work, no one knows for sure. By the numbers, current treatments/protocols, and there are probably over 40 at this point, don't do all that much better if at all than those who do not follow one, which is about 70%-80% that do well overall. FWIW, I do take a DMD and I can't say with certainty whether it really works or not..



From the linked article:

"Almost 80% of participants survived without experiencing any increase in disability or relapse of clinical symptoms.

Need I say more?


"HSCT is the only treatment that is reversing the disability and some people even walked after it."

Actually, this statement is quite inaccurate. ALL treatents/protocols, inclusing HSCT work for some but not all. AND amazingly, their success rates are typically around 80%!
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