LR1234 wrote:Could someone remind me of what BG12 is actually?? I know its fumeric acid or something like that but I read somewhere on this forum that it can be synthesised via a supplement but just can't find the post.
Fumaric acid is a metabolite involved in the citric acid cycle in mitochondria. BG12 is the dimethyl ester of fumaric acid or dimethyl fumarate. BG12 induces oxidative stress in the cell and causes it to switch into defense mode by activating the transcription factor Nrf2. Once activateed, Nrf2 goes into the nucleus and turns on the transcription of several genes for cellular detox antioxidant enzymes. There are abundant molecules in nature that have a similar function. One example is curcumin from turmeric, but there are many more.
Here is the chemical structure of dimethyl fumarate.
It is the carbon/carbon double bond, C=C, conjugated with the carbonyl groups, C=O, that give it the ability to oxidize thiol groups, -SH, and thereby activate Nrf2.
Compare the above structure to those depicted in figure 2 of this free review paper on Nrf2 activators.https://www.thieme-connect.com/ejournal ... 088302.pdf
Here are some links to some prior posts which discuss BG12 and Nrf2.
BG12 at Ectrimsgeneral-discussion-f1/topic18288.html
Curcumin's pro-oxidant activitynatural-approach-f27/topic19461.html#p188097
Old treaments, new tricksgeneral-discussion-f1/topic17487.html
There are other posts and threads, but these should give you plenty to get you started.