BG12

Discuss Tecfidera (BG-12, dimethyl fumarate) as an oral treatment for multiple sclerosis.

BG12

Postby LR1234 » Mon Apr 30, 2012 2:58 pm

Could someone remind me of what BG12 is actually?? I know its fumeric acid or something like that but I read somewhere on this forum that it can be synthesised via a supplement but just can't find the post.
Thanks
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Re: BG12

Postby FLJhawk » Mon Apr 30, 2012 5:21 pm

Are you thinking of Malic Acid?
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Re: BG12

Postby NHE » Mon Apr 30, 2012 8:14 pm

LR1234 wrote:Could someone remind me of what BG12 is actually?? I know its fumeric acid or something like that but I read somewhere on this forum that it can be synthesised via a supplement but just can't find the post.


Fumaric acid is a metabolite involved in the citric acid cycle in mitochondria. BG12 is the dimethyl ester of fumaric acid or dimethyl fumarate. BG12 induces oxidative stress in the cell and causes it to switch into defense mode by activating the transcription factor Nrf2. Once activateed, Nrf2 goes into the nucleus and turns on the transcription of several genes for cellular detox antioxidant enzymes. There are abundant molecules in nature that have a similar function. One example is curcumin from turmeric, but there are many more.

Here is the chemical structure of dimethyl fumarate.

    Image

It is the carbon/carbon double bond, C=C, conjugated with the carbonyl groups, C=O, that give it the ability to oxidize thiol groups, -SH, and thereby activate Nrf2.

Compare the above structure to those depicted in figure 2 of this free review paper on Nrf2 activators.
https://www.thieme-connect.com/ejournal ... 088302.pdf


Here are some links to some prior posts which discuss BG12 and Nrf2.

BG12 at Ectrims
general-discussion-f1/topic18288.html

BG12 Efficacy
gilenya-f43/topic17488.html#p173498

BG12 Activity
chronic-cerebrospinal-venous-insufficiency-ccsvi-f40/topic19565.html#p188961

Curcumin's pro-oxidant activity
natural-approach-f27/topic19461.html#p188097

Old treaments, new tricks
general-discussion-f1/topic17487.html

There are other posts and threads, but these should give you plenty to get you started.


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Re: BG12

Postby LR1234 » Mon May 14, 2012 12:43 pm

Thanks for the info guys
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Re: BG12

Postby gibbledygook » Fri May 18, 2012 9:42 am

Hey L, I've asked my private quack to see if he can get this stuff cheaply as it's already licensed for other conditions, psoriasis, I think. Dr Kapoor seemed very enthusiastic about it since its side effect profile is good.
Will keep you posted.
Am going to see Dr Sclafani in July.
3 years antibiotics, 06/09 bilateral jug stents at C1, 05/11 ballooning of both jug valves, 07/12 stenting of renal vein, azygos & jug valve ballooning,
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Re: BG12

Postby LR1234 » Fri May 18, 2012 11:13 am

Cool thanks gg. Hope all goes well with dr sclafani.
How is dr k? I am no longer a patient of his..weirdly i kinda miss the fella! Was with him 4 ten years
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Re: BG12

Postby gibbledygook » Fri May 18, 2012 11:31 am

Hi,

Kapoor is well. He's always friendly and kind. He appears in one of the NHS magazines on disease modifying drugs. It's good to know they don't waste money on actors! Like in America.

I can't wait for Sclafani to investigate my renal vein as I strongly suspect this may have a severe blockage but we'll see.

Has your MS settled back down? I really hope so.
3 years antibiotics, 06/09 bilateral jug stents at C1, 05/11 ballooning of both jug valves, 07/12 stenting of renal vein, azygos & jug valve ballooning,
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Re: BG12

Postby LR1234 » Fri May 18, 2012 1:04 pm

Ish...It has given some real issues cognitively:( I had a really bad cog relapse, lesions everywhere in frontal lobe but I am busy doing brain training exercises hoping to re-route and connect some new neurons!

(I will FB you) x

x
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Re: BG12

Postby CureOrBust » Sat Sep 22, 2012 2:20 am

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Re: BG12

Postby stillfighting » Sun Oct 07, 2012 8:52 pm

Actually fumeric acid is a supplement and can be gotten at any online vitamin store. It's cheap too.. don't rush in I have read it is also useless.
I have seen where it will not do us any good to take. Something about the wrong (esters) I think.
It's just not the right compound.
Something like that, but close.
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