I am in week 6 of tecfidera. I have suffered all of the side effects at some point in time, some worse that others. Week 1-2 was fairly easy. Flushing, itching and internal heat caused by the flushing. Week three was an absolute nightmare. Mainly due to the upper abdominal pain. Literally had me in tears at some points, quitting the drug many times while going through the pain. Not knowing if I was better off standing, laying down, curling into a ball or stretching out. Sometimes wanting to do them all at once. I didn't quit because I am determined to see if I will adapt to this drug because I'm hoping it lives up to its hype. And I will never put myself through that week three again. One thing that helped me with the abdominal pains is Gas X. If taken when I get the first sign of the stomach pain it really did work. Now mind you in that week 3 it only lessened fairly intolerable pain but now it gets rid of it. Week 3 also had much nausea, pepto bismal helped, some vomiting and a few days of the runs. All a pain but manageable. And none of them had me laying on the floor in an empty office at work in pain like the stomach issues did. So, like clockwork at the beginning of week 4 the debilitating pain eased up to a very manageable level especially with my new best friend GasX. I do take an aspirin with breakfast and take the tecfidera about 45-60 minutes after eating. I do try to have a few fried egg whites & turkey bacon for breakfast, there does seem to be something about the protein. I just had 3 days with no bad side effects, tummy gurgling, minor gas etc but his morning at 3 am the upper abdominal pain was back & bad enough to keep me awake for 2 hrs. I did take the gas x but if I don't catch it at the beginning it's not as effective. I am going to try to stick it out and hopefully my WBC wont have fallen and I can continue it. I think what has already been discovered about this drug is it is ridiculously individualized regarding side effects & fixes and there is no 1 solution fits all. So if something works for you that hasn't been mentioned here please share. If it helps just 1 of us stay on the drug it's worth it. And if you've hit that week 3 wall and you're getting creamed like I did don't quit, it should get better. Good luck all.