Hi everybody, new to this board, not new to MS. Symptoms began in 1991, diagnosed in 1998.
First reactions to Tecfidera: Hands became numb and itchy, and the (maddening) feeling slowly crept up my arms to about the elbows before it started to go away. This continued for about two weeks, then disappeared. This may be the "flushing" that had been mentioned. A good deal of gastric upset, spent the first week or so next to the bathroom. All side effects seemed to dissipate, and after 3 weeks, there were none to speak of.
The show so far: Just prior to receiving the medicine, one of the worst exacerbations ever. I went out to get the mail, fell, and could not get back up. I could not even crawl back to the house, some construction workers saw me fall and helped me get back to the house. Thank God for them. That afternoon, I received the Tecfidera. The next day I could walk. Without the cane, it was a major miracle. I actually felt like a "normal" person. But as time wore on, perhaps in two weeks, it was back to being the hobbling old cripple I was prior to the medication.
It was rather like a course of corticosteroids... you feel better, but it's only temporary. But at least, unlike the steroids, I didn't inflate like a balloon.
I did take Rebif (made me too suicidal) and Copaxone (couldn't take the injection-site reactions). So time will tell, I guess, if there are any long-term effects. But of all the availible treatments, Tecfidera seems to be the least evil, so based on my personal experience with it, I can recommend it without hesitation.
I wish all of you the best.