Hi! I have had success with taking two Benadryl tablets as soon as I feel the flushing coming on. My face can look like a tomato! By now, I can recognize when it is starting---my ears start to tingle and feel strange--and I pop the tablets. It prevents that red face and rash on my arms and chest. If it occurs on two consecutive doses, I take the Benadryl about 30 min before taking the Tecfidera as a precaution, and it works. Not sure if this will help you, but I hope that it does.