Hi, I am new to this site. I wanted to share my experiences with Tecfidera that have been, for the most part, the discovery of the miracle drug we all hope to find. After having minor neurological problems for years, 5 or 6 years ago after an MRI I was finally diagnosed with MS or something like it. At that time I was started on Rebif. Ugly! After 1 ½ year went off all meds. After about 2 years I decided another MRI was in order and I was correct. There was activity that needed treatment. A new neurologist and new medication. This time Copoxone for about 1 year. Ugly again!! About that time approval for Tecfidera was looming on the horizon. I approached my neurologist about getting started on the Tecfidera and he showed very little interest in the idea. He appeared to be more concerned with keeping the cash register ringing rather than my quality of life. Because he did not share my sense of urgency in getting away from the Copaxone it was time to find a new neurologist. Easier said than done. Once finding a new neurologist willing to jump on the Tecfidera bandwagon, I finally got started. Well, almost. First I had to undergo heavy metal chelation to treat a high blood lead level condition. Chelation was no fun and may have contributed to some of the bumps in the road getting started with the Tecfidera. Got through the first week of titration with little trouble but after going to full dosage started experience lack of appetite, nausea 1 time, fatigue. Decided to continue daily a.m. dose, but skip every other p.m. dose until things improved. After about 2 weeks things got better and went to full a.m. and p.m. dosage. It was at time I also decided to consider Ladymac’s advice. I am not a breakfast person but her advice concerning more protein should be given a try. Now I start off my day with coffee, O.J., yogurt and 1 hard boiled egg. Miracle!! Still not a breakfast person, but it seems to be working. One thought to consider, I recommend anyone having GI issues to include yogurt or some form of probiotic in their diet. For those frequently taking antibiotics, consider Florastor. Normally I am reluctant to preach but in this case there needs to be an exception made. Try to avoid taking care of your nutritional needs at fast food restaurants. If I had a nickel for every time that someone I knew who had a case of the “24 hour flu” that could be linked to fast food consumption, I’d never have to work again for the rest of my life. I know it is a pain in the butt, but learning good food preparation and handling practices can go a long way to keeping bad food problems to a minimum. Today’s sermon second topic is avoiding medications that cause more problems than they cure. This is something that is best not left in the hands of others. I have been blown off by doctors numerous times when I express concerns about medication side effects. When I quit taking Copaxone I was able to quit taking prednisone and blood pressure medication as well as others necessitated by side effects. There is enough information available to those willing to take the trouble to look to determine if your meds are causing more problems that they cure. Be proactive in your treatment. If you are being blown off by your doctor over concerns of any sort , consider a new doctor. Unfortunately, there are too many doctors who’s biggest concern is keeping that cash register ringing. I sincerely hope that yours is not one of them. I’ve had two. That was two too many. The third time seems to be the charm. It has been a long time since I felt this good and I have never felt anywhere this good during treatment. That says a lot for Tecfidera. If you’re having problems, don’t give up without exploring all options. Good Luck, gramcjk.