sharon60 wrote:I have been on Tecfidera for 7 months now, 240 mg 2x a day. I have noticed increased bone pain over the past probably month. I have had some minor balance problems walking before the Tecfidera, but the pain is so bad, I am having problems walking a short distance at work and at home. Forget trying to get off my couch at home. I work full time at a hospital and by the time I get home around 4:00 pm, I am exhausted. I have also noticed that I am falling asleep like someone has drugged me around 7:00/7:30 at night. Since being on Tecfidera, I have gained around 15 pounds and bloated all the time, look like I am about 7 months along with a pregnancy. I have also noticed I am getting very aggitated with co-workers about silly little things. I am sleeping fine, take a 5mg melatonin dissolving tablet when I am not sleepy, works great. According to the nurses that I have talked to at the Tecfidera site, after this much time on the drug, I should not have any flushing. My problem other than the above, the Tecfidera has taken away the psorrisis, so hesitant to go off of it.
Welcome to ThisIsMS, sharon60.
Although you have not asked for any opinions, I offer you my thoughts: I am focused on vitamin B12 deficiency recently; and I wonder if you have had a serum B12 test – many of your symptoms could be due to B12 deficiency. I encourage you to watch the following video:
"Everything You Want Your Doctor to Know about Vitamin B12"http://www.youtube.com/watch?v=BvEizypoyO0
I highly recommend this 50-minute documentary from the filmmaker Elissa Leonard, featuring Sally Pacholok, RN, BSN & her husband Jeffrey Stuart, D.O. (authors of the book, Could It Be B12? An Epidemic of Misdiagnoses); Lawrence Solomon, M.D., hematologist with Yale Medical School; Ralph Green, M.D., hematologist at UC Davis; and Donald Jacobsen, PhD, at the Cleveland Clinic (Homocysteine Research Lab).
@1:23 "The neurological manifestations well precede the hematological manifestations."
@1:46 "In 1948 scientists isolated a red crystalline pigment and named it vitamin B12. It is a primordial molecule responsible for the health of all the DNA in all our cells. The Framingham Offspring Study suggests 40% of Americans have suboptimal B12."
As I recall, bone pain is mentioned in Part 1: The story of JJ; balance problems are specifically mentioned in Part 2.
Signs and Symptoms of B12 Deficiency:
Sore Mouth or TongueFatigue
Stomach and G.I. Problems
Limb Movement Disorders
Thoughts of Suicide
I think it may be worth investigating.