kelyce522 wrote:What is your source? I have called the nurse help line for tecfidera and spoke with my neuro... The nurse line was no help, but my neuro stated to do the 2 month detox like all other meds.... My search online turned nothing up either, including the tecfidera FAQ page. I am very curious!! Thank you for you input!!
as an example...
In humans, dimethyl fumarate is extensively metabolized by esterases, which are ubiquitous in the gastrointestinal tract, blood, and tissues, before it reaches the systemic circulation. Further metabolism of MMF occurs through the tricarboxylic acid (TCA) cycle, with no involvement of the cytochrome P450 (CYP) system. MMF, fumaric and citric acid, and glucose are the major metabolites in plasma.
Exhalation of CO2 is the primary route of elimination, accounting for approximately 60% of the TECFIDERA dose. Renal and fecal elimination are minor routes of elimination, accounting for 16% and 1% of the dose respectively. Trace amounts of unchanged MMF were present in urine.
The terminal half-life of MMF is approximately 1 hour and no circulating MMF is present at 24 hours in the majority of individuals. Accumulation of MMF does not occur with multiple doses of TECFIDERA."
source: http://dailymed.nlm.nih.gov/dailymed/lo ... 84b9b49151